Effects of delayed administration of octreotide in acute experimental pancreatitis

The Journal of Surgical Research
O KaplanY Skornick

Abstract

Multiple therapeutic modalities studied for acute pancreatitis often show a poor correlation between results obtained in experimental studies and results of clinical trials. One of the main reasons for this discrepancy is that in most experimental studies the drugs were administered immediately after induction of pancreatitis, whereas in the clinical setting there is almost always a delay between the onset of the disease and initiation of the treatment. We studied the effects of a delayed treatment with octreotide, the synthetic analogue of the hormone somatostatin, on acute experimental pancreatitis in rats. The disease was induced by intraparenchymal injections of 0.5 ml 5% sodium taurocholate, and octreotide (10 mg/kg/day s.c.) was started either 4 or 12 hr later. Subcutaneous saline injections were used in controls. One-half of the animals of each study group was sacrificed after 36 hr, and the following parameters were examined: pancreatic weight, plasma pH, serum calcium and amylase, and histopathological damage. The same parameters, as well as survival, were assessed after 20 days in the remaining rats. Neither intrapancreatic saline injections, nor octreotide administration without the induction of pancreatitis, caused ...Continue Reading

Citations

Oct 5, 2007·Journal of Gastroenterology and Hepatology·Frank Axel WengerJoachim Michael Müller
Aug 23, 2002·Acta Ophthalmologica Scandinavica·U CelikerH Celiker
Aug 4, 2001·Acta Clinica Belgica·J Ponette, A Wilmer
Mar 1, 2000·The Journal of Laboratory and Clinical Medicine·R GreenbergO Kaplan
Jul 9, 2004·World Journal of Gastroenterology : WJG·László CzakóJános Lonovics
Jan 5, 1999·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·J MartonG Farkas

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