Effects of delayed treatment with nebracetam on neurotransmitters in brain regions after microsphere embolism in rats

British Journal of Pharmacology
Satoshi TakeoS Oshikawa

Abstract

1. The effects of delayed treatment with nebracetam, a novel nootropic drug, on neurotransmitters of brain regions were examined in rats with microsphere embolism-induced cerebral ischaemia. 2. Cerebral ischaemia was induced by administration of 900 microspheres (48 microns) into the internal carotid artery. The rats with stroke-like symptoms were treated p.o. with 30 mg kg-1 nebracetam twice daily. The levels of acetylcholine, dopamine, noradrenaline, 5-hydroxytryptamine (5-HT) and their metabolites in the cerebral cortex, striatum and hippocampus of animals with microsphere embolism were determined by high performance liquid chromatography (h.p.l.c.) on the 3rd and 7th days after the operation. 3. Although the microsphere embolism induced significant changes in most of the neurotransmitters and some of their metabolites in the brain regions, the delayed treatment with nebracetam partially restored only the hippocampal 5-HT and the striatal dopamine metabolite contents on the 3rd day. 4. The hippocampal in vivo 5-HT synthesis, but not the striatal dopamine synthesis, was attenuated in rats with microsphere embolism on the 3rd day, but was restored by treatment with nebracetam. In vivo striatal dopamine turnover rate of the rat...Continue Reading

References

Feb 1, 1992·Japanese Journal of Pharmacology·K IwasakiM Fujiwara
Jan 1, 1992·Stroke; a Journal of Cerebral Circulation·S TakeoK Fujimori
Feb 1, 1974·Archives of Neurology·D A Drachman, J Leavitt
Jul 30, 1982·Science·R T BartusA S Lippa
Jun 1, 1995·Stroke; a Journal of Cerebral Circulation·N TakagiS Takeo
Mar 1, 1993·Stroke; a Journal of Cerebral Circulation·K MiyakeH Kaijihara

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Citations

Dec 14, 2001·Lancet·S Shorvon
Jul 2, 2003·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Keiko Takagi, Satoshi Takeo

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