PMID: 11927448Apr 3, 2002Paper

Effects of delaying fluid resuscitation on an injury to the systemic arterial vasculature

Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine
James F HolmesDavid H Wisner

Abstract

To determine the effects of delaying fluid on the rate of hemorrhage and hemodynamic parameters in an injury involving the arterial system. Twenty-one adult, anesthetized sheep underwent left anterior thoracotomy and transection of the left internal mammary artery. A chest tube was inserted into the thoracic cavity to provide a continuous measurement of blood loss. The animals were randomly assigned to one of three resuscitation protocols: 1) no fluid resuscitation (NR), 2) standard fluid resuscitation (SR) begun 15 minutes after injury, or 3) delayed fluid resuscitation (DR) begun 30 minutes after injury. All of the animals in the two resuscitation groups received 60 mL/kg of lactated Ringer's solution over 30 minutes. Blood loss and hemodynamic parameters were measured throughout the experiment. Total hemorrhage volume (mean +/- SD) at the end of the experiment was significantly lower (p = 0.006) in the NR group (1,499 +/- 311 mL) than in the SR group (3,435 +/- 721 mL) or the DR group (2,839 +/- 1549 mL). Rate of hemorrhage followed changes in mean arterial pressure in all groups. Hemorrhage spontaneously ceased significantly sooner (p = 0.007) in the NR group (21 +/- 14 minutes) and the DR group (20 +/- 15 minutes) than in ...Continue Reading

Citations

Mar 14, 2003·The Journal of Trauma·Richard L GeorgeLoring W Rue
Mar 12, 2005·The Journal of Trauma·El Rasheid ZakariaPatrick D Harris
Dec 9, 2010·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Nathan J WhiteKevin R Ward
Dec 15, 2011·Polski przeglad chirurgiczny·M Brent HaickChristopher K Zarins
Jan 8, 2010·Annals of Vascular Surgery·Simon RinckenbachJean-Georges Kretz
Dec 2, 2008·The Journal of Surgical Research·Jared G ClayFelix D Battistella
Oct 3, 2006·Annals of Emergency Medicine·Chien-Chang LeeWen-Jone Chen
Feb 18, 2010·Shock·Heena P Santry, Hasan B Alam
Aug 30, 2012·The Journal of Trauma and Acute Care Surgery·Marquinn D DukeJuan Carlos Duchesne
Dec 13, 2002·The Journal of Trauma·Jack J M LigtenbergJan G Zijlstra
Dec 13, 2002·The Journal of Trauma·Peter J Shirley, Anne E Weaver

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