PMID: 108730Mar 22, 1979

Effects of delta-aminolaevulinic acid administration on social behaviour in the laboratory mouse

Psychopharmacology
M G CutlerF G Ewart

Abstract

Ethologic analysis has been used to study the behavioural effects following injection of delta-aminolaevulinic acid (ALA) in mice. After a dose level of 1.6 mmol ALA/kg, male and female mice showed periods of immobility and scanned less frequently than saline-injected controls. Exploration of the cage was significantly reduced in frequency in treated males, many elements of social and sexual investigation were reduced in treated females, and no elements of aggression were seen in treated males. Gait was abnormal and movement lethargic in animals showing the greatest degree of immobility. Righting reflexes and the response to stimuli of noise and touch remained normal. After a dose level of 0.8 mmol ALA/kg, no significant behavioural effects were detectable.

References

Nov 27, 1978·Life Sciences·M G CutlerM R Moore
Sep 1, 1975·Journal of Toxicology and Environmental Health·Y SuketaT Yamamoto
Jul 15, 1977·Experientia·C A PierachC J Watson
Jan 1, 1976·General Pharmacology·G TunnicliffR E Wimer
Dec 1, 1975·Environmental Health Perspectives·L W ReiterD F Cahill
Jan 11, 1976·Food and Cosmetics Toxicology·G L KennedyJ C Calandra
Jan 5, 1971·Biochimica Et Biophysica Acta·D BeckerS Kramer
Feb 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·D S FeldmanC J Watson
Nov 1, 1974·Journal of Neurochemistry·D BeckerJ D Viljoen
Jan 1, 1970·Brain : a Journal of Neurology·V P SweeneyA K Asbury
Oct 6, 1962·Nature·S A BARKERM STACEY

Citations

Nov 1, 1983·Neurochemical Research·V A RussellJ J Taljaard
Jan 1, 1984·Critical Reviews in Toxicology·T Beritić
Jan 1, 1987·Annals of the New York Academy of Sciences·M R MooreA A Yeung-Laiwah
Oct 1, 1985·Journal of Neurology, Neurosurgery, and Psychiatry·A C LaiwahA GOLDBERG

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