Effects of Delta-tocotrienol Supplementation on Liver Enzymes, Inflammation, Oxidative stress and Hepatic Steatosis in Patients with Nonalcoholic Fatty Liver Disease

The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology
Muhammad Amjad PervezShamrez Khan

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a growing public health problem worldwide and is associated with increased morbidity and mortality. Currently, there is no definitive treatment for this disease. δ-Tocotrienol has potent anti-inflammatory and antioxidant properties and may reduce liver injury in NAFLD. The present study aims to evaluate the efficacy and safety of δ-tocotrienol in the treatment of NAFLD. The present study was a randomized, double-blind, placebo-controlled pilot study conducted in patients aged > 20 years, belonging to both sexes, having ultrasound-proven fatty liver disease, having a fatty liver index (FLI) of ≥ 60, and persistent elevation of alanine transaminase. A total of 71 patients were assigned to receive either oral δ-tocotrienol (n=35, 300 mg twice daily) or placebo (n=36) for 12 weeks. At the baseline and at the end of the study, clinical and biochemical parameters, including lipid profile, liver function tests, high-sensitivity C-reactive protein (hs-CRP), and malondialdehyde (MDA) were measured. Body mass index and FLI were calculated, and ultrasound grading of hepatic steatosis was performed. Out of 71 enrolled patients, 64 patients, 31 in the δ-tocotrienol group and 33 in the placebo gro...Continue Reading

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Citations

Jan 30, 2019·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Hassan AfzaliZatollah Asemi
Jul 18, 2020·Clinical Science·Lei ZhangXiao-Jing Zhang
Aug 19, 2020·Journal of Gastroenterology and Hepatology·Andreas VadarlisMichail Chourdakis
Feb 27, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Mohammad Reza EmamiNaheed Aryaeian
Jul 20, 2021·The Cochrane Database of Systematic Reviews·Oluyemi KomolafeKurinchi Selvan Gurusamy
Sep 22, 2020·Complementary Therapies in Medicine·Shuping ZuoJianlei Tang

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