PMID: 2110370Feb 1, 1990Paper

Effects of demethylchlortetracycline phototoxicity on the structure and functions of rat liver mitochondria

Photochemistry and Photobiology
S TakagiT Wakabayashi

Abstract

The phototoxic effects of demethylchlortetracycline (DMCT) with UVA radiation on isolated rat liver mitochondria were studied. DMCT at concentration of 21.5 microM with 5.53 x 10(-2) J cm-3 of UVA was found to be a potent uncoupler of oxidative phosphorylation. DMCT alone also uncoupled mitochondria but at higher concentrations (105 microM). ATPase activity was remarkably induced in mitochondria exposed to DMCT (21.5 microM) plus UVA (120% of DNP-stimulated ATPase activity). Content of ATP in such mitochondria when measured after addition of ADP was much smaller than that in control mitochondria. Ultrastructurally, mitochondria treated either with DMCT (21.5 microM) or with UVA alone stayed in the condensed configuration. On the other hand, uncoupled mitochondria treated with DMCT plus UVA became swollen and were changed into the orthodox configuration.

References

Aug 1, 1975·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·T WakabayashiH Kimura
Nov 1, 1975·Photochemistry and Photobiology·R NilssonG Wennersten
Jun 1, 1986·The Journal of Investigative Dermatology·J PietteA Van de Vorst
Sep 1, 1986·The Journal of Investigative Dermatology·C R SheaT Hasan
Apr 1, 1985·The Journal of Investigative Dermatology·M Bjellerup, B Ljunggren
Dec 1, 1985·The Journal of Investigative Dermatology·M BjellerupB Ljunggren
Sep 1, 1984·The Journal of Investigative Dermatology·T HasanD Abdulah
May 17, 1982·European Journal of Biochemistry·A M ReboudJ P Reboud
Jan 20, 1961·Science·H G DU BUY, J L SHOWACRE
May 1, 1961·Archives of Dermatology·N ORENTREICHT A TROMOVITCH

❮ Previous
Next ❯

Citations

Oct 1, 1995·Journal of the American Academy of Dermatology·J W GouldC A Elmets
Jan 24, 1998·Journal of Photochemistry and Photobiology. B, Biology·V ChekulayevA Kahru
Jan 1, 1994·Lasers in Surgery and Medicine·Y MorimotoH Nakamura

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.