Effects of demographic factors on survival time after a diagnosis of amyotrophic lateral sclerosis

Neuroepidemiology
Heather M JordanWendy E Kaye

Abstract

The Agency for Toxic Substances and Disease Registry established surveillance projects to determine the incidence, prevalence, and demographic characteristics of persons with Amyotrophic Lateral Sclerosis (ALS) in defined geographic areas. There is a need to characterize and account for the survival and prognostic factors among a population-based cohort of ALS cases in the United States. A cohort of incident cases diagnosed from 2009-2011 in New Jersey was followed until death or December 31, 2013, whichever happened first. Survival was assessed using Kaplan-Meier curves and Cox proportional hazards regression was used to identify prognostic factors. Sixty-four percent of incident cases died between 2009 and 2013, 93.7% specifically from ALS. Among the 456 cases studied in the survival analysis, the median survival from diagnosis was 21 months; 46% of cases survived longer than two years from diagnosis. Older age predicted shorter survival. While there is some indication of differences because of sex, race, and ethnicity, these differences were not statistically significant when accounting for age. New Jersey mortality data were queried to determine the vital status of a cohort of incident ALS cases and used to investigate rela...Continue Reading

Citations

Sep 25, 2015·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Laurie WagnerWendy Kaye
Nov 1, 2015·Journal of Neurology·Benoît MarinPierre Marie Preux
Jun 22, 2016·Journal of Health Care Chaplaincy·Kevin J FlannellyKatherine R B Jankowski
Sep 7, 2019·PloS One·Christiana A DemetriouEleni Zamba-Papanicolaou
Oct 31, 2015·PloS One·Mirian Conceicao MouraLuiz Augusto Casulari
Jul 14, 2020·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Miguel Oliveira SantosMamede De Carvalho

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