Effects of Deoxynivalenol and Zearalenone on the Histology and Ultrastructure of Pig Liver.

Toxins
Natalia SkiepkoBogdan Lewczuk

Abstract

The purpose of this study was to determine the effects of single and combined administrations of deoxynivalenol (DON) and zearalenone (ZEN) on the histology and ultrastructure of pig liver. The study was performed on immature gilts, which were divided into four equal groups. Animals in the experimental groups received DON at a dose of 12 μg/kg body weight (BW) per day, ZEN at 40 μg/kg BW per day, or a mixture of DON (12 μg/kg BW per day) and ZEN (40 μg/kg BW). The control group received vehicle. The animals were killed after 1, 3, and 6 weeks of experiment. Treatment with mycotoxins resulted in several changes in liver histology and ultrastructure, including: (1) an increase in the thickness of the perilobular connective tissue and its penetration to the lobules in gilts receiving DON and DON + ZEN; (2) an increase in the total microscopic liver score (histology activity index (HAI)) in pigs receiving DON and DON + ZEN; (3) dilatation of hepatic sinusoids in pigs receiving ZEN, DON and DON + ZEN; (4) temporary changes in glycogen content in all experimental groups; (5) an increase in iron accumulation in the hepatocytes of gilts treated with ZEN and DON + ZEN; (6) changes in endoplasmic reticulum organization in the hepatocytes...Continue Reading

References

Feb 1, 1988·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·D B PreluskyJ D Miller
Jun 1, 1995·Journal of Hepatology·K IshakR N MacSween
Apr 1, 1996·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·J W Halliday, J Searle
Oct 31, 2002·Advances in Food and Nutrition Research·Roger A Coulombe
Apr 4, 2003·The Veterinary Journal·E ConkováH Seidel
Jul 15, 2003·Clinical Microbiology Reviews·Edwin S Van AmersfoortJohan Kuiper
Jun 16, 2004·Archives of Animal Nutrition·S DänickeS Döll
May 24, 2005·The Veterinary Journal·H MalekinejadJ Fink-Gremmels
Jun 24, 2005·Journal of Animal Physiology and Animal Nutrition·S DänickeK-H Ueberschär
Aug 27, 2005·Veterinary Research·Hassan MalekinejadJohanna Fink-Gremmels
Oct 11, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S Cavret, S Lecoeur
Aug 31, 2007·World Journal of Gastroenterology : WJG·Ross-M GrahamDebbie Trinder
Aug 31, 2007·World Journal of Gastroenterology : WJG·Yves Deugnier, Bruno Turlin
Dec 5, 2009·The Journal of Veterinary Medical Science·Mei DongSusumu Kumagai
Jun 17, 2010·Histology and Histopathology·Davide PoveroMaurizio Parola
Oct 20, 2010·Best Practice & Research. Clinical Gastroenterology·Susanne N Weber, Hermann E Wasmuth
May 17, 2011·Preventive Veterinary Medicine·Susanne Döll, Sven Dänicke
Jan 14, 2012·Pregnancy Hypertension·Graham J Burton, Hong-Wa Yung
Apr 9, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Lam Yim Murphy WanHani El-Nezami
May 27, 2014·Toxins·Philippe Pinton, Isabelle P Oswald
Dec 4, 2014·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Juliana R GerezAna Paula F L Bracarense
Dec 8, 2015·Cellular & Molecular Immunology·Hui PengZhigang Tian
Dec 19, 2015·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Bogdan LewczukMaciej Gajęcki
Feb 9, 2016·Journal of Hepatology·Antonello Pietrangelo
Aug 22, 2017·Asian-Australasian Journal of Animal Sciences·Kondreddy Eswar ReddySung Dae Lee
May 29, 2018·Fungal Biology·John E Hallsworth
Aug 8, 2019·Medicines·Andronicos Yiannikourides, Gladys O Latunde-Dada
Mar 28, 2020·PloS One·Shivasharanappa NayakwadiKanthesh M Basalingappa
Apr 9, 2020·Environmental Pollution·Changwon YangWhasun Lim
May 20, 2020·Toxicon : Official Journal of the International Society on Toxinology·Magdalena Buszewska-Forajta

❮ Previous
Next ❯

Citations

Oct 24, 2020·Toxins·Maciej T GajęckiŁukasz Zielonka
Apr 4, 2021·Toxins·Cristina Valeria BulgaruIonelia Taranu
Aug 18, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yongsong BaiAnshan Shan
Sep 9, 2021·Journal of Animal Physiology and Animal Nutrition·Fengyang WuBaojiang Chen

❮ Previous
Next ❯

Methods Mentioned

BETA
electron microscopy

Software Mentioned

Statistica
Pannoramic Viewer

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.