Effects of depleted uranium after short-term exposure on vitamin D metabolism in rat

Archives of Toxicology
E TissandiéM Souidi

Abstract

Uranium is a natural radioactive heavy metal. Its toxicity has been demonstrated for different organs, including bone, kidney, liver and brain. Effects of an acute contamination by depleted uranium (DU) were investigated in vivo on vitamin D(3) biosynthetic pathway. Rats received an intragastric administration of DU (204 mg/kg) and various parameters were studied either on day 1 or day 3 after contamination. Cytochrome P450 (CYP27A1, CYP2R1, CYP27B1, CYP24A1) enzymes involved in vitamin D metabolism and two vitamin D(3)-target genes (ECaC1, CaBP-D9K) were assessed by real time RT-PCR in liver and kidneys. CYP27A1 activity was measured in liver and vitamin D and parathyroid hormone (PTH) level were measured in plasma. In acute treated-rats, vitamin D level was increased by 62% and decreased by 68% in plasma, respectively at day 1 and at day 3, which paralleled with a concomitant decrease of PTH level (90%) at day 3. In liver, cyp2r1 mRNA level was increased at day 3. Cyp27a1 activity decreased at day 1 and increased markedly at day 3. In kidney, cyp27b1 mRNA was increased at days 1 and 3 (11- and 4-fold respectively). Moreover, ecac1 and cabp-d9k mRNA levels were increased at day 1 and decreased at day 3. This work shows for the...Continue Reading

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Citations

Jul 24, 2008·Archives of Toxicology·J G Hengstler, H M Bolt
Nov 30, 2006·International Journal of Toxicology·M SouidiY Guéguen
Nov 4, 2008·Journal of Toxicology and Environmental Health. Part a·M A McDiarmidK S Squibb
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Apr 28, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R RacineM Souidi
May 27, 2008·The Journal of Steroid Biochemistry and Molecular Biology·E TissandiéM Souidi
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Aug 1, 2013·Human & Experimental Toxicology·C PoissonY Gueguen
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Jun 13, 2017·Toxicology and Applied Pharmacology·Alexandra C MillerDavid Brenner
Aug 7, 2020·Journal of Environmental Radioactivity·Yonghong RanYuhui Hao

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