PMID: 7544444Apr 1, 1995Paper

Effects of deprenyl on monoamine oxidase and neurotransmitters in the brains of MPTP-treated aging mice

Neurochemical Research
M Gupta, H L Wiener

Abstract

Deprenyl is a selective monoamine oxidase B (MAO-B) inhibitor and has been used in the treatment of Parkinson's disease. However, it is not known whether deprenyl effects are symptomatic or pharmacological. Aging mice were partially lesioned with MPTP. Control and MPTP-treated mice were given deprenyl in drinking water for 14 days. Brain tissue (including the striatum, olfactory tubercle and cerebral cortex) was assayed for MAO-B and neurotransmitter levels. The results show that deprenyl treatment, given alone or after MPTP, reduced MAO-B activity in all the three regions. No change was seen in dopamine (DA), 3,4-dihydroxyphenyl acetic acid (DOPAC), and homovanillic acid (HVA) content in any of the three areas. Cortical norepinephrine (NE) levels were also unaltered. However, striatal serotonin (5-HT) levels were decreased while its metabolite, 5-HIAA levels were significantly increased in the olfactory tubercle in animals receiving deprenyl alone. These data suggest that deprenyl treatment reduces MAO-B activity in regions in addition to the striatum without affecting norepinephrine, dopamine (DA) and its metabolites.

References

Jul 1, 1989·Journal of Neuroscience Research·H L WienerH Sershen
Nov 16, 1989·The New England Journal of Medicine·UNKNOWN Parkinson Study Group
Jan 1, 1989·Acta Neurologica Scandinavica. Supplementum·I Shoulson
Aug 1, 1986·Journal of Neurochemistry·M Naoi, T Nagatsu
Oct 1, 1987·Pharmacology, Biochemistry, and Behavior·H SershenA Lajtha
Apr 30, 1984·Biochemical and Biophysical Research Communications·K ChibaN Castagnoli

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.