Mar 1, 1976

Effects of derivatives of cyclic amp and cyclic gmp on contraction force of cat papillary muscles

European Journal of Pharmacology
R D WilkersonW J George


Right ventricular kitten papillary muscles were incubated with dibutyryl adenosine 3',5'-monophosphate (dbcAMP) at varying concentrations as low as 1 X 10(-4)M. A positive inotropic effect was observed with all concentrations of dbcAMP. Concomitant administration of 5 X 10(-4)M monobutyryl guanosine 3',5'-monophosphate (mbcGMP) and 1-2 X 10(-4)M dbcAMP prevented the inotropic response observed when dbcAMP was used alone. When higher doses of dbcAMP were used (5 X 10(-4) M, 10 X 10(-4) M), there was no significant difference in the inotropic response seen between control tissues and papillary muscles pretreated with mbcGMP.

  • References4
  • Citations12
  • References4
  • Citations12


Mentioned in this Paper

Myocardial Contraction
Drug Interactions
Structure of Papillary Muscle
Bucladesine, Barium (1: 1) Salt
Cyclic GMP
Dose-Response Relationship, Drug
In Vitro [Publication Type]
Felis catus

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