PMID: 5909698Mar 1, 1966

Effects of desferrioxamine in patients with iron-loading with a simple method for estimating urinary iron

Journal of Clinical Pathology
M S LOSOWSKY

Abstract

Desferrioxamine produced marked increases in urinary iron excretion in three patients with very gross iron loading. The magnitude of the response to desferrioxamine was not closely related to the amount of iron seen in liver biopsy sections. In two patients with less severe iron loading, desferrioxamine produced no significant increase in urinary iron content. In the patients who responded, the effect of desferrioxamine did not diminish with repeated doses even over periods of up to a year.The effectiveness of desferrioxamine was not increased by intravenous administration, water diuresis, mersalyl, or ammonium chloride.A simple method for estimation of urinary iron is described, necessitating a minimum of glassware, and sufficiently accurate for clinical purposes.

References

May 9, 1957·The New England Journal of Medicine·S C FINCH, R N BARNETT
Nov 1, 1958·Clinica Chimica Acta; International Journal of Clinical Chemistry·R J HENRYN CHIAMORI
Jul 1, 1961·Annals of Internal Medicine·R B BYRD, T COOPER
Aug 1, 1963·Acta Haematologica·F WOEHLER
Mar 1, 1964·Archives of Internal Medicine·J R WALSHV LANGE
Jul 1, 1964·Journal of Clinical Pathology·J FIELDING, M BRUNSTROEM
Dec 1, 1964·Archives of Internal Medicine·Y F HWANG, E B BROWN
Oct 7, 1964·Annals of the New York Academy of Sciences·R S SMITH
Jan 1, 1965·British Journal of Haematology·M S LOSOWSKY, R HALL
Jan 1, 1965·Journal of Clinical Pathology·J FIELDING

Citations

Jan 1, 1983·Critical Reviews in Clinical Laboratory Sciences·G D McLarenR W Kellermeyer
Apr 1, 1989·Baillière's Clinical Haematology·J P Kaltwasser, E Werner

Related Concepts

Asiderotic Anemia
Sideroblastic Anemia
Desferal
Hereditary Hemochromatosis
Iron
Fibrosis, Liver
Urine

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