Effects of desflurane, sevoflurane and halothane on postinfarction spontaneous dysrhythmias in dogs

Acta Anaesthesiologica Scandinavica
E NovalijaZ J Bosnjak

Abstract

Although desflurane (DES) and sevoflurane (SEV) have desirable features for use in patients with coronary artery disease, their effects on ventricular dysrhythmias following infarction are less known. We therefore examined the effects of DES and SEV upon spontaneous postinfarction ventricular dysrhythmias in dogs, and compared those effects to the well-established antidysrhythmic effects of halothane (HAL) in this model. After institutional approval, the left anterior descending coronary artery was ligated in 16 adult mongrel dogs during isoflurane anesthesia. All dogs developed acute myocardial infarction and severe ventricular tachydysrhythmias. Twenty-two hours after infarction, dogs were anesthetized at 1.5 MAC with desflurane (10.8%) followed by sevoflurane (3.5%) in the treatment group (n = 10), or halothane (1.3%) in the other group (n = 6). Anesthetic gases were allowed to equilibrate for at least 20 min at each end-tidal concentration. At this time, the ECG was recorded for 9 min and evaluated for the number of ventricular ectopic and sinoatrial beats and summed duration of ventricular tachycardia. DES and SEV reduced the average rate of total ventricular ectopic beats by 40 +/- 4% and 42 +/- 4%, respectively. HAL decr...Continue Reading

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Citations

Mar 18, 2005·Journal of Feline Medicine and Surgery·Almir Pereira SouzaNewton Nunes
May 23, 2003·The New England Journal of Medicine·Jason A CampagnaStuart A Forman
Jan 3, 2008·American Journal of Veterinary Research·Priscilla H JoynerJonathan M Sleeman
Sep 4, 2010·Journal of Cardiovascular Electrophysiology·Jeff E MandelFrancis E Marchlinski
Mar 20, 2015·Anesthesia and Analgesia·Alexander J C MittnachtAman Mahajan
Oct 12, 2010·Toxicology and Industrial Health·H TürkanB Karahalil
Dec 17, 2008·Natural Product Research·K XiaoL-J Xuan
Feb 27, 2013·Anesthesia and Analgesia·Lance S PatakDavid Bradley

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