Effects of desmopressin acetate on platelet aggregation, von Willebrand factor, and blood loss after cardiac surgery with extracorporeal circulation

Circulation
T L AnderssonE Vinge

Abstract

The effects of desmopressin acetate (DDAVP) on platelet aggregation and the von Willebrand factor antigen (vWF:Ag) were studied in 19 patients undergoing cardiac surgery with extracorporeal circulation. The patients represented one of five blocks in a randomized double-blind placebo-controlled parallel group trial on the effects of DDAVP on postoperative bleeding after uncomplicated coronary artery bypass operations. After termination of extra-corporeal circulation, DDAVP (0.3 microgram/kg body wt) or its vehicle was infused into a peripheral vein throughout 15 minutes. The increase in factor VIII coagulant activity after infusion did not differ between the groups but there was a significantly larger increase in vWF:Ag levels in DDAVP-treated patients. The aggregatory response to adenosine-diphosphate (ADP) and ristocetin showed a normal pattern and was not significantly different between the two groups. As compared with placebo, DDAVP did not decrease the bleeding time or the postoperative blood loss. We conclude that DDAVP causes an increase in vWF:Ag levels but does not alter platelet aggregation, bleeding time, or blood loss in uncomplicated coronary artery bypass patients.

References

May 1, 1975·British Journal of Haematology·P M MannucciB Robertson
Aug 1, 1986·American Journal of Hematology·H TakahashiA Shibata
Jan 1, 1988·European Journal of Clinical Pharmacology·M Köhler, A Harris
Mar 15, 1988·Thrombosis Research·R J CuthbertC A Ludlam
Jan 1, 1986·Psychotherapy and Psychosomatics·D M GarnerM J Irvine
Feb 1, 1985·Scandinavian Journal of Clinical and Laboratory Investigation·S LammeH O Sjögren
Jan 1, 1974·Scandinavian Journal of Haematology·L Holmberg, I M Nilsson
Jul 1, 1983·The Journal of Clinical Investigation·Z M RuggeriR R Montgomery
Jan 6, 1983·The New England Journal of Medicine·P M MannucciT S Zimmerman

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Citations

Jan 13, 2001·The Annals of Thoracic Surgery·W C OliverM H Ereth
Apr 1, 1991·Transfusion Medicine Reviews·S Schulman
Jan 5, 2008·Haemophilia : the Official Journal of the World Federation of Hemophilia·M Cattaneo
Apr 1, 1991·Journal of Cardiothoracic and Vascular Anesthesia·D L ReichD M Thys
Jun 1, 1991·Journal of Cardiothoracic and Vascular Anesthesia·T Hackmann, S C Naiman
Aug 1, 1993·Journal of Cardiothoracic and Vascular Anesthesia·G DiltheyJ A Richter
Dec 1, 1994·The Annals of Thoracic Surgery·S E FremesC D Naylor
Feb 22, 2005·European Journal of Anaesthesiology·D De BelsE Van der Vorst
May 9, 2007·Seminars in Cardiothoracic and Vascular Anesthesia·Emad B MossadJohn Apostolakis
Sep 12, 2000·Haemophilia : the Official Journal of the World Federation of Hemophilia·P M Mannucci
Mar 1, 1997·European Journal of Anaesthesiology. Supplement·B J Hunt
Jul 12, 2017·The Cochrane Database of Systematic Reviews·Michael J DesboroughLise J Estcourt
Oct 1, 1994·The Journal of Bone and Joint Surgery. American Volume·T A KarnezisP Reilly

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