PMID: 3750366Jan 1, 1986Paper

Effects of development, aging, and renal and hepatic insufficiency as well as hemodialysis on the plasma concentrations of albumin and alpha 1-acid glycoprotein: implications for binding of drugs

Therapeutic Drug Monitoring
G M PacificiH U Schulz

Abstract

The concentrations of total proteins, albumin, alpha 1-acid glycoprotein (AGP), and nonesterified fatty acids (NEFA) were measured in the serum of 21 newborn infants and 13 children, aged 1-13 months, and in the plasma of 31 volunteers, 25 patients with renal failure, 27 patients with cirrhosis, 39 uremic patients undergoing hemodialysis, and 20 elderly subjects. The concentration of albumin in the volunteers was higher than in all other groups. The concentration of AGP in the volunteers was higher than in newborn infants but lower than in elderly subjects, patients with renal failure, and those with chronic uremia. The concentration of NEFA in volunteers was higher than in newborn infants and patients with renal failure and lower than in elderly subjects and patients with cirrhosis.

Citations

Jan 1, 1987·European Journal of Clinical Pharmacology·G M PacificiH J Frercks
May 1, 1994·Psychopharmacology·G MannensJ Heykants
Jun 19, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Kasra Shakeri-NejadJasper Dingemanse
Aug 10, 2000·Anesthesiology Clinics of North America·S L Shafer
Apr 1, 1997·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·P DostertI Poggesi
Apr 20, 2000·British Journal of Clinical Pharmacology·G EversonR Z Turncliff
Apr 20, 2000·British Journal of Clinical Pharmacology·F AweekaR Z Turncliff
Apr 5, 2000·Clinical Pharmacokinetics·M K Grandison, F D Boudinot
Oct 31, 2002·Clinical Pharmacokinetics·Jane Alcorn, Patrick J McNamara
Jul 15, 2015·Expert Opinion on Drug Metabolism & Toxicology·Tran H TranRobert A Mangione
Aug 10, 2001·Drug Metabolism Reviews·Z H Israili, P G Dayton
Jan 11, 2012·Molecular Aspects of Medicine·Gabriella FanaliPaolo Ascenzi
Aug 1, 1989·British Journal of Clinical Pharmacology·A VianiG M Pacifici
Aug 1, 1989·Journal of Clinical Pharmacology·F M Demotes-MainardH C Albin
Aug 9, 2005·Early Human Development·Gian Maria Pacifici
Dec 21, 2002·British Journal of Clinical Pharmacology·Louise RoyUNKNOWN Martine Leblanc
Jun 7, 2002·AAPS PharmSci·Patrick J McNamara, Jane Alcorn
Nov 28, 2013·Pharmaceuticals·Gian Maria Pacifici
Jan 1, 1991·Annals of the New York Academy of Sciences·D J PostJ Papaconstantinou
Dec 1, 1994·Journal of Veterinary Pharmacology and Therapeutics·Y PerezM Arboix
Jan 26, 2007·Journal of Pharmacological Sciences·Ronald A SmuldersTimothy J Hoon
Nov 1, 2011·Critical Reviews in Clinical Laboratory Sciences·Bhushan M KapurPeter Selby
Sep 3, 2016·Pharmaceutical Research·Nilay ThakkarDaniel Gonzalez
Jul 1, 1989·DICP : the Annals of Pharmacotherapy·M D Reed
Dec 30, 2018·Pharmaceutical Research·Sherri A Smith, Nigel J Waters
Jan 27, 2019·Drugs & Aging·Carole LinBan C H Tsui

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