Effects of deworming on malnourished preschool children in India: an open-labelled, cluster-randomized trial.

PLoS Neglected Tropical Diseases
S AwasthiD A Bundy

Abstract

More than a third of the world's children are infected with intestinal nematodes. Current control approaches emphasise treatment of school age children, and there is a lack of information on the effects of deworming preschool children. We studied the effects on the heights and weights of 3,935 children, initially 1 to 5 years of age, of five rounds of anthelmintic treatment (400 mg albendazole) administered every 6 months over 2 years. The children lived in 50 areas, each defined by precise government boundaries as urban slums, in Lucknow, North India. All children were offered vitamin A every 6 months, and children in 25 randomly assigned slum areas also received 6-monthly albendazole. Treatments were delivered by the State Integrated Child Development Scheme (ICDS), and height and weight were monitored at baseline and every 6 months for 24 months (trial registration number NCT00396500). p Value calculations are based only on the 50 area-specific mean values, as randomization was by area. The ICDS infrastructure proved able to deliver the interventions. 95% (3,712/3,912) of those alive at the end of the study had received all five interventions and had been measured during all four follow-up surveys, and 99% (3,855/3,912) were...Continue Reading

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References

Feb 1, 1994·Journal of Pediatric Gastroenterology and Nutrition·D BrasseurJ Duchateau
Aug 1, 1993·American Journal of Public Health·D L PelletierJ P Habicht
Jan 1, 1997·The American Journal of Clinical Nutrition·R J StoltzfusL Savioli
Mar 1, 1997·Psychological Bulletin·W E Watkins, E Pollitt
Dec 10, 1999·Tropical Medicine & International Health : TM & IH·N M BeasleyD A Bundy
Oct 24, 2001·Indian Journal of Pediatrics·S Awasthi, V K Pande
May 29, 2002·Tropical Medicine & International Health : TM & IH·T R ManiK Satyanarayana
Aug 23, 2003·BMJ : British Medical Journal·Shally AwasthiLorenzo Savioli
Dec 3, 2003·Trends in Parasitology·Nilanthi R de SilvaLorenzo Savioli
Jan 7, 2006·Health Education & Behavior : the Official Publication of the Society for Public Health Education·Joel GittelsohnLisa K Staten
Aug 11, 2006·Annals of Tropical Medicine and Parasitology·J Utzinger, J Keiser
Oct 19, 2007·The Cochrane Database of Systematic Reviews·D C Taylor-RobinsonP Garner

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Citations

Mar 28, 2008·PLoS Neglected Tropical Diseases·Marco AlbonicoLorenzo Savioli
Jan 28, 2009·PLoS Neglected Tropical Diseases·Donald A P BundyEdward Miguel
Dec 18, 2013·The American Journal of Tropical Medicine and Hygiene·Parminder S SuchdevLeAnne M Fox
May 4, 2016·The American Journal of Tropical Medicine and Hygiene·Serene A JosephTheresa W Gyorkos
Nov 17, 2017·BMC Public Health·Winter Maxwell ThayerNeff Walker
Jun 1, 2018·PLoS Neglected Tropical Diseases·Nathan C LoEran Bendavid
May 1, 2009·Mucosal Immunology·P J Cooper
Jul 24, 2015·The Cochrane Database of Systematic Reviews·David C Taylor-RobinsonPaul Garner
Sep 12, 2019·The Cochrane Database of Systematic Reviews·David C Taylor-RobinsonPaul Garner
Jul 25, 2019·The American Journal of Tropical Medicine and Hygiene·Nader MohamedBineyam Taye
Aug 30, 2008·Current Opinion in Infectious Diseases·Alice Chijioke Eziefula, Michael Brown

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Clinical Trials Mentioned

NCT00396500

Software Mentioned

Prepilot
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