Effects of dexamethasone, all-trans retinoic acid, vitamin D(3) and interferon-alpha on FO myeloma cells

Chemotherapy
Feyyaz OzdemirCem Boruban

Abstract

Since multiple myeloma responds poorly to conventional chemotherapy or radiotherapy, new therapeutic approaches are needed. This study investigated the effects of dexamethasone, all-trans retinoic acid (ATRA), the active metabolite of vitamin D(3) [1,25(OH)(2)D(3)] and interferon-alpha on FO mouse myeloma cells (non-immunoglobulin-secreting myeloma cell line) in single drug or drug combination groups in vitro. Apoptosis ratio and change in cell counts in 4 single drug groups (dexamethasone, ATRA, vitamin D(3) and interferon-alpha) and 6 combination drug groups (dexamethasone + vitamin D(3,) dexamethasone + ATRA, dexamethasone + interferon-alpha, vitamin D(3) + ATRA, vitamin D(3) + interferon-alpha, interferon-alpha + ATRA) were compared with the control group. When treatment groups were compared with the control group, there was a significant increase in apoptosis in all, but this was most prominent in the group treated with dexamethasone alone. The apoptosis ratios were 0.10 and 6.82% in the control and dexamethasone-only groups, respectively. We also found that there was a significant decrease in cell count, particularly in the dexamethasone-only, ATRA-only, and ATRA-vitamin D(3) combination groups. ATRA, interferon-alpha, vi...Continue Reading

References

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Citations

Oct 28, 2015·Cancer Investigation·Beate Lauter, Ingo G H Schmidt-Wolf
Dec 24, 2011·Cancer Letters·Minji KimMaurizio Chiriva-Internati
Jun 2, 2014·The Lancet. Diabetes & Endocrinology·Lorenz C HofbauerFranz Jakob
Nov 26, 2009·The Journal of International Medical Research·Andrej PlesnicarB Kores Plesnicar
Jun 3, 2021·International Journal of Molecular Sciences·Vanessa InnaoSebastiano Gangemi
Aug 28, 2021·International Journal of Molecular Sciences·Massimo De MartinisSebastiano Gangemi

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis