Effects of dexamethasone and Salvia miltiorrhizae on the small intestine and immune organs of rats with severe acute pancreatitis.

Inflammation
Zhang XipingZhang Fangjie

Abstract

To observe the protecting effects and mechanisms of Dexamethasone and Salviae miltiorrhizae on intestinal mucosa and immune organs (spleen, thymus and lymph node) in rats with severe acute pancreatitis (SAP). The rats were randomly divided into sham-operated, model control, Dexamethasone treated group and Salviae miltiorrhizae treated group. At 3, 6 and 12 h after operation, the mortality rate, pathological changes of intestinal mucosa and immune organs as well as the contents of serum PAF, IL-1 beta and sIL-2R were observed, respectively. The mortality rate and the contents of PAF (at 3 and 6 h), IL-1 beta (at all time points) and sIL-2R (at 3 and 6 h) as well as the pathological scores of thymus (at all time points) and spleen (at 3 h) in Dexamethasone treated group were significantly lower than those in model control groups (P < 0.05). The contents of PAF (at 3 and 12 h), IL-1 beta (at 6 and 12 h) and sIL-2R (at 3 and 6 h) as well as the pathological scores of thymus (at all time points) and spleen (at 3 and 12 h) in Salviae miltiorrhizae treated group were markedly lower than those in model control groups (P < 0.05). Since both Dexamethasone and Salvia miltiorrhizae can reduce the contents of serum PAF, sIL-2R and IL-1 beta...Continue Reading

References

Mar 24, 2000·The Journal of Surgical Research·W Z WangF N Miller
Dec 17, 2002·Journal of Hepato-biliary-pancreatic Surgery·Rohit Makhija, Andrew N Kingsnorth
Jul 10, 2003·American Journal of Respiratory and Critical Care Medicine·Thierry L DugernierJérôme Pugin
Feb 21, 2006·World Journal of Gastroenterology : WJG·Li-Rong Liu, Shi-Hai Xia
Apr 26, 2006·Scandinavian Journal of Gastroenterology·Changbin ShiRoland Andersson
Jul 18, 2006·Intensive Care Medicine·Denis R MorelCatherine M Pastor
Apr 4, 2007·Annals of the New York Academy of Sciences·Riyo EnomotoEibai Lee
Aug 11, 2007·Journal of Pharmacological Sciences·Riyo EnomotoEibai Lee
Feb 8, 2008·Journal of Zhejiang University. Science. B·Xi-ping ZhangHan-qin Chen
Feb 22, 2008·Mediators of Inflammation·Zhang XipingTian Hua
May 7, 2008·Bulletin of Experimental Biology and Medicine·V Y ArionL A Zakharova
Jun 21, 2008·World Journal of Gastroenterology : WJG·Xi-Ping ZhangTong-Fa Ju

❮ Previous
Next ❯

Citations

Oct 15, 2013·The American Journal of Chinese Medicine·Xiao-Dong WenChun-Su Yuan
Aug 14, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ching-Chung TsaiTong-Rong Tsai
Jun 27, 2012·Annals of the New York Academy of Sciences·Lila G Glotfelty, Gail A Hecht
Nov 6, 2012·Journal of Zhejiang University. Science. B·Jing-min OuPing Yan
Apr 4, 2015·Chinese Journal of Natural Medicines·Chun-Yan SuLu-Ping Qin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.