Effects of dexamethasone, celecoxib, and methotrexate on the histology and metabolism of bone tissue in healthy Sprague Dawley rats

Clinical Interventions in Aging
Yanzhi LiuLiao Cui

Abstract

To investigate the long-term effects of three antiarthritics, namely dexamethasone, celecoxib, and methotrexate on the histology and metabolism of intact bone tissue in rats. Thirty-two 12-week-old healthy female Sprague Dawley rats were randomly allocated into four groups: 1) control (saline, daily); 2) dexamethasone (2 mg/kg, twice weekly); 3) celecoxib (50 mg/kg, daily); and 4) methotrexate (0.5 mg/kg, twice weekly). The drugs were administered to the rats for 12 weeks and the animals were weighed on a weekly basis. The femurs and lumbar vertebrae were harvested for bone mineral density and bone mechanical properties analyses. The proximal tibiae were processed for bone histomorphometry and micro-computed tomography analyses. The following results were obtained: 1) dexamethasone strongly inhibited bone formation rate accompanied with a decrease in bone mineral density and bone biomechanical properties; 2) celecoxib stimulated bone resorption, leading to a decrease of bone mass and femur biomechanic properties; and 3) methotrexate caused bone loss and bone quality deterioration to a lesser extent due to the increase of the bone turnover rate on the proximal tibial metaphysis of the rats. This study provides a comparative prof...Continue Reading

Citations

May 5, 2017·International Journal of Molecular Sciences·Daohua XuQian Chen
Nov 16, 2019·The Kaohsiung Journal of Medical Sciences·Zhe-Hai LiYu-Chi Wu
Mar 6, 2018·Frontiers in Pharmacology·Abeer K MalkawiAnas M Abdel Rahman
Nov 1, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·F RobinP Guggenbuhl
Oct 23, 2020·International Journal of Molecular Sciences·Siti Fadziyah Mohamad AsriElvy Suhana Mohd Ramli
May 1, 2021·Journal of Clinical Medicine·Meletios RozisDimitrios Stergios Evangelopoulos

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