Effects of dexmedetomidine on respiratory mechanics and control of breathing in normal rats

Respiratory Physiology & Neurobiology
Fatima C FernandesP R Rocco

Abstract

Dexmedetomidine is a highly selective and specific alpha(2)-adrenergic agonist, with sedative, analgesic, and sympatholytic activities. The aim of the present study was to define the effects of DMED in respiratory mechanics in normal rats. In addition, lung morphometry was studied to determine whether the physiological changes reflected underlying morphological changes defining the sites of action of dexmedetomidine. Arterial blood gases were also determined. Twelve adult Wistar rats were randomly assigned to two groups of six animals each: PENTO and DMED. In PENTO group animals were sedated (diazepam, 5mg, i.p.) and anaesthetised with pentobarbital sodium (20mgkg(-1) i.p.). The rats of the DMED group received dexmedetomidine (250mugkg(-1) i.p. followed by intravenous infusion of 0.5mugkg(-1)h(-1)). In spontaneously breathing rats, minute ventilation, respiratory frequency, and neuromuscular inspiratory drive were lower in dexmedetomidine group, which also presented hypercapnia, whereas tidal volume, inspiratory, expiratory, and total respiratory cycle times were higher in dexmedetomidine group compared to the PENTO group. During mechanical ventilation, respiratory mechanical parameters were similar in both groups. These findin...Continue Reading

Associated Clinical Trials

References

Aug 1, 1992·Anesthesia and Analgesia·M H ZornowM Matsumoto
Nov 1, 1985·Acta Physiologica Scandinavica·N Grundström, R G Andersson
May 4, 2000·British Journal of Anaesthesia·G S RetaW A Zin
Jul 18, 2002·Intensive Care Medicine·Tomoyo NishidaTakashi Mashimo
Aug 27, 2004·Anesthesiology·Michael A E Ramsay, David L Luterman

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Citations

Mar 27, 2012·The Journal of Surgical Research·Volkan HanciEmine Yilmaz Sipahi
Sep 26, 2008·Basic & Clinical Pharmacology & Toxicology·Mohammad TariqHaseeb Ahmad Khan
Jan 16, 2008·Current Opinion in Anaesthesiology

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