PMID: 8991862Aug 1, 1996Paper

Effects of dextran sulphate sodium on intestinal epithelial cells and intestinal lymphocytes

Gut
J NiD Hollander

Abstract

The effects of dextran sulphate sodium (DSS) on mouse intestinal epithelial cells and intraepithelial lymphocytes were analysed to investigate the mechanism by which DSS induces colitis and tumours in mice. Cytotoxicity of DSS towards intestinal epithelial cells and intestinal intraepithelial lymphocyte hybridomas or fresh intestinal intraepithelial lymphocytes seems to have concentration, time, and cell type dependency with increasing concentrations and time causing increased cytotoxicity. Integrin alpha 4 expression was marginally down regulated by 0.5% of DSS, while alpha M290 expression was up regulated. DSS inhibits the binding of 9.1 gamma delta cells to both extracellular matrix (ECM) and epithelial cells. Conversely at high concentrations it increases binding to all ECM except poly-L-lysine. Various cytokines including TGF beta, interleukin 2, and tumour necrosis factor alpha as well as prostaglandin alter the expression of the integrin alpha 4 and M290 subunits at the cell surface, and also alter the adhesion of 9.1 gamma delta cells to epithelial monolayers. The expression of a large number of cell adhesion molecules expressed on intraepithelial lymphocytes is affected by a combination of the abundant gut cytokine TGF...Continue Reading

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Citations

Jan 9, 2007·Inflammatory Bowel Diseases·Diane MarshallAlastair D G Lawson
Jan 6, 2010·Inflammatory Bowel Diseases·Sun-Mi ParkMarcus E Peter
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Oct 25, 2007·Digestive Diseases and Sciences·Keiko KataokaYoshinari Ohnishi
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Aug 19, 2014·International Immunopharmacology·Ahmed G Abdel SalamMona F Schaalan

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