Effects of diabetes and insulin on hepatic delta6 desaturase gene expression

Biochemical and Biophysical Research Communications
Omar J RimoldiR R Brenner

Abstract

It has been recognized that rat liver microsomal Delta6 desaturation activity is defective in experimental diabetes, a fact that may be reverted by means of insulin treatment. In the present study, we used streptozotocin-induced diabetic rats in order to determine the regulatory role of insulin on the expression of hepatic Delta6 desaturase gene. The abundance of hepatic Delta6 desaturase mRNA in the diabetic rats is sevenfold lower than in the control. Insulin administration to diabetic rats induces Delta6 desaturase mRNA eightfold within 24 h. The effect of insulin on the Delta6 desaturase mRNA was inhibited 70% with dibutyryl-cAMP and theophylline administration and 90% by cycloheximide administration. Therefore, our data demonstrate that the activity of hepatic Delta6 desaturase in response to insulin is, at least in part, regulated by pretranslational events that require the synthesis of an unknown protein(s).

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Citations

Jun 11, 2004·Annual Review of Nutrition·Manabu T Nakamura, Takayuki Y Nara
Jun 6, 2003·Bioscience, Biotechnology, and Biochemistry·Yasuhiko ShimadaKimio Sugiyama
Jul 31, 2002·Biochemical and Biophysical Research Communications·Takayuki Y NaraManabu T Nakamura
Dec 11, 2013·Archives of Physiology and Biochemistry·Lea CanettiAlicia Leikin-Frenkel
Jun 26, 2007·Pediatrics International : Official Journal of the Japan Pediatric Society·Tomoo OkadaEmiko Saito
Aug 4, 2015·Critical Reviews in Food Science and Nutrition·Xianyong MaChaoqiang Lai
Dec 10, 2002·Biochemical and Biophysical Research Communications·Wei Song HeManabu T Nakamura
Sep 28, 2016·Lipids in Health and Disease·Marc Pilon
Mar 15, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M A MontanaroR R Brenner
Apr 22, 2017·Biochimica Et Biophysica Acta. Biomembranes·Javier S Perona
Feb 6, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Natalie L WeirMichael Y Tsai
Jan 23, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Suzette L PereiraPradip Mukerji
Jan 23, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M T Nakamura, T Y Nara
Jan 23, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Rodolfo R Brenner
Jul 26, 2021·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Hui Gyu ParkJ Thomas Brenna
Aug 3, 2021·Journal of Diabetes and Its Complications·Christina E KostaraVasilis Tsimihodimos

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