Abstract
The pancreatic islets of the golden hamster have an extremely high monoamine oxidase (MAO) activity and norepinephrine (NE) concentration. To determine the cellular component responsible for these high values, we assayed MAO activity and NE concentration in collagenase-isolated islets from normal, streptozotocin-induced diabetic, and 6-hydroxydopamine (6-OHDA) induced sympathectomized golden hamsters. There was a 53% reduction in islet MAO activity in the diabetic hamsters, with no alteration in islet MAO activity in the sympathectomized ones, suggesting that the pancreatic B cells contain a large proportion of the MAO activity. There was a 98% reduction in islet NE concentration in the sympathectomized hamsters, with no alteration in islet NE concentration in the diabetic hamsters, suggesting that the adrenergic nerve endings in the islets contain the majority of the NE. There was no alteration in the MAO activity or NE concentration in th cerebral cortex, pituitary gland, liver, kidney, acinar pancreas, or heart of diabetic hamsters. Although the MAO activity of the hypothalamus was not altered, the diabetic hamsters had a 166% increase in NE and a 199% increase in dopamine in their hypothalamus, with no change in these amine...Continue Reading
References
May 1, 1975·Acta diabetologica latina·J M Feldman, B Chapman
Mar 1, 1979·Diabetes·R T ZernJ M Feldman
Sep 1, 1979·Diabetologia·J M FeldmanJ A Blalock
Jan 1, 1979·Hormone Research·J M FeldmanR T Zern
Feb 1, 1979·Metabolism: Clinical and Experimental·L DemischN Seiler
Dec 1, 1975·Diabetologia·J M Feldman, B Chapman
Feb 1, 1975·Life Sciences·D P HenryR H Williams
Jul 1, 1973·Journal of Neurochemistry·J T Coyle, D Henry
Aug 1, 1966·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·D KvistbergA Lazarow
Nov 1, 1969·The Journal of Clinical Investigation·A JunodA E Renold
Jan 1, 1968·Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie·H Thoenen, J P Tranzer
Jan 1, 1973·Annual Review of Pharmacology·H Thoenen, J P Tranzer
Jul 1, 1974·Physiological Reviews·S C Woods, D Porte
Sep 1, 1974·Diabetes·J M Feldman, B Chapman
Jun 1, 1970·Diabetologia·D L Coleman, K P Hummel
Apr 1, 1971·Diabetologia·B N BrodoffJ Hagedoorn
Jan 31, 1969·Science·R A MuellerJ Axelrod
Apr 1, 1980·Diabetologia·R T ZernJ M Feldman
Jul 1, 1963·The Biochemical Journal·C N HALES, P J RANDLE
Dec 1, 1963·Biochemical Pharmacology·R J WURTMAN, J AXELROD
Nov 1, 1938·The Journal of Clinical Investigation·D A Scott, A M Fisher
Citations
Jan 1, 1987·Journal of Neural Transmission·S L Welle, J Feldman
Jul 30, 2008·Muscle & Nerve·Amanda Martins BavieraIsis C Kettelhut
Mar 1, 1991·Physiology & Behavior·T J BartnessM P Maharaj
Apr 21, 1987·Brain Research·M S BitarM Linnoila
Jul 1, 1988·Behavioural Brain Research·J M Feldman