Oct 18, 2019

Effects of diabetes mellitus on reparative osteogenesis

Wiadomości lekarskie : organ Polskiego Towarzystwa Lekarskiego
Oksana K MelekhovetsIryna I Yakovtsova

Abstract

Introduction: Chronic hyperglycemia as the main link in DM pathogenesis leads to systemic vessels and nerves lesion with chronic bone complications development consequently. The aim: To evaluate influence of hyperglycemia on reparative osteogenesis after perforated tibial fracture in rats. Materials and methods: A total of 30 white adult rats were subdivided into two groups: 15 healthy rats in Group 1 (control) and 15 rats with alloxan induced hyperglycemia in Group 2 (investigated) and were carried out of experiment on the 10th, 20th and 30th day after the fracture. Hyperglycemia in rats was verificated as the postprandial glycemic rate ≥ 8,0 mmol/l. Tibia diaphysis fracture was modeled by a cylindrical defect with a diameter of 2 mm with portable frezer. Morphological evaluation. A complex morphological studies included histological, morphometric and immunohistochemical examination. Results: This is confirmed by an increase in MMP-9 expression in connective tissue, a decrease in TGF-β expression in all phases, an increase in the expression of CD3 and CD20 and a marked decrease in the expression of all vascular markers. During hyperglycemia, incomplete blood supply to the tissues occurs, necrosis of bone and soft tissues devel...Continue Reading

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Mentioned in this Paper

Biological Markers
Study
Necrosis
Transforming Growth Factor beta
Pathogenesis
Immunohistochemistry
Angiogenic Process
Blood Vessel
Tibial Fractures
Callus - plant part

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