PMID: 9536292Apr 16, 1998Paper

Effects of diacerhein in an accelerated canine model of osteoarthritis

Osteoarthritis and Cartilage
Kenneth D BrandtM Albrecht

Abstract

To determine whether diacerhein has a disease-modifying effect in an accelerated canine model of osteoarthritis. Fourteen adult mongrel dogs underwent unilateral L4-S1 dorsal root ganglionectomy (DRG), followed 3 weeks later by ipsilateral anterior cruciate ligament transection. Seven dogs received diacerhein (15-20 mg/kg) daily throughout the interval between DRG and sacrifice, eight weeks after ligament transection. The other seven dogs served as OA controls. The mean volume of synovial fluid obtained from the OA knee of the diacerhein-treated dogs was approximately 40% less than that from the OA knee of the controls. In addition, diacerhein appeared to reduce the severity of fibrillation (femoral condyle) and full-thickness ulceration (trochlear ridge) of the articular cartilage and the level of collagenase activity in extracts of the OA cartilage, and to increase net PG synthesis in the OA cartilage, although none of the above changes were statistically significant. The differences between the diacerhein group and untreated OA controls, even though not statistically significant, suggest that diacerhein was active in this rapidly progressive model of OA. Because changes associated with initiation of OA may be different than ...Continue Reading

References

Nov 1, 1979·Analytical Biochemistry·T E Cawston, A J Barrett
Jan 1, 1989·European Journal of Clinical Pharmacology·G La VillaP Gentilini
Aug 1, 1989·The Journal of Clinical Investigation·D D DeanJ F Woessner
Apr 1, 1988·Arthritis and Rheumatism·A M Bendele, J F Hulman
Feb 28, 1972·Biochimica Et Biophysica Acta·E D Harris, S M Krane
Apr 1, 1983·The Journal of Pharmacy and Pharmacology·S Franchi-MicheliL Zilletti
Feb 15, 1984·The Biochemical Journal·D D Dean, J F Woessner
Feb 1, 1984·Arthritis and Rheumatism·J M Williams, K D Brandt
Jun 1, 1995·Annals of Internal Medicine·K D Brandt
Apr 1, 1994·Arthritis and Rheumatism·M NguyenB Amor
Oct 1, 1962·Analytical Biochemistry·T BITTER, H M MUIR

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Citations

Jun 28, 2001·European Journal of Pharmacology·T Tamura, K Ohmori
Jul 20, 2002·European Journal of Pharmacology·Tadafumi TamuraNagatomo Takafumi
Feb 11, 2004·Joint, Bone, Spine : Revue Du Rhumatisme·Pascal Richette, Thomas Bardin
Apr 1, 2010·Therapeutic Advances in Musculoskeletal Disease·Johanne Martel-Pelletier, Jean-Pierre Pelletier
Jul 3, 2015·BMC Veterinary Research·María PermuyAntonio González-Cantalapiedra
Nov 24, 1999·Osteoarthritis and Cartilage·T TamuraK Nakamura
May 12, 2000·Osteoarthritis and Cartilage·F MoldovanJ Martel-Pelletier
Apr 13, 2002·Osteoarthritis and Cartilage·A C A MarijnissenF P J G Lafeber
Oct 21, 2015·International Journal of Rheumatic Diseases·Morgana Duarte da SilvaAdair Roberto Soares Santos
Mar 3, 2011·American Journal of Physiology. Endocrinology and Metabolism·Xiaoyan ShengYing Qin Zang
Nov 10, 2005·Rheumatology·G Verbruggen

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