Effects of diadenosine polyphosphates on systemic and regional hemodynamics in anesthetized rats

Kidney & Blood Pressure Research
M KhattabE Schlatter

Abstract

Diadenosine polyphosphates (Ap4A, Ap5A, Ap6A) induce vasodilatation or vasoconstriction in various isolated vessels and influence central and peripheral hemodynamics. The influence of diadenosine polyphosphates on hemodynamics was studied in anesthetized rats in vivo. Mean arterial blood pressure (MABP) and heart rate (HR) measured in the carotid artery decreased with Ap4A, Ap5A, and Ap6A. Renal blood flow (RBF), femoral blood flow (FBF) and cardiac output (CO) were evaluated by an ultrasonic transit-time method. Renal superficial blood flow (RSBF) was measured by laser Doppler flowmetry. CO, RBF and RSBF were decreased initially by all three diadenosine polyphosphates. FBF was also slightly decreased. Total peripheral (TPR), renal (RVR) and femoral (FVR) vascular resistances were calculated. TPR was transiently increased by the dinucleotides following by a decrease. RVR and, to a lesser extent, FVR were also increased. These data show that diadenosine polyphosphates have effects on both the heart and the peripheral blood vessels. The effects on the heart and MABP were dominated by bradycardia and hypotension. In the kidney, diadenosine polyphosphates induced a predominant vascoconstriction. The effects on skeletal muscle blood...Continue Reading

Citations

Jun 9, 2000·Kidney International·G GabriëlsM Steinhausen
Nov 8, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Martin SteinmetzEberhard Schlatter
Jul 6, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·Martin SteinmetzEberhard Schlatter
Feb 16, 2005·British Journal of Pharmacology·Miroslawa Szczepańska-KonkelStefan Angielski
Apr 26, 2011·European Journal of Pharmacology·Angel Luis García-VillalónGodofredo Diéguez
Feb 16, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M KhattabH EL-Kashef
May 20, 2006·The Journal of Pharmacology and Experimental Therapeutics·Sergei MelnikNatalia Lozovaya
Jul 20, 2002·The Journal of Pharmacology and Experimental Therapeutics·Martin SteinmetzEberhard Schlatter
May 8, 2003·Canadian Journal of Physiology and Pharmacology·M DuvalP D' Orléans-Juste
May 16, 2001·American Journal of Physiology. Renal Physiology·E W Inscho

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