Effects of diazepam and flumazenil on minimum alveolar concentrations for dogs anesthetized with isoflurane or a combination of isoflurane and fentanyl

American Journal of Veterinary Research
P W HellyerC Kollias-Baker

Abstract

To determine the effect of a constant-rate infusion of fentanyl on minimum alveolar concentration (MAC) of isoflurane and to determine the interaction between fentanyl and a benzodiazepine agonist (diazepam) and antagonist (flumazenil) in isoflurane-anesthetized dogs. 8 mixed-breed adult dogs. Dogs were anesthetized with isoflurane 3 times during a 6-week period. After a 30-minute equilibration period, each MAC determination was performed in triplicate, using standard techniques. Fentanyl was administered as a bolus (10 microg/kg of body weight, IV) that was followed by a constant infusion (0.3 microg/kg per min, IV) throughout the remainder of the experiment. After determining isoflurane-fentanyl MAC in triplicate, each dog received saline (0.9% NaCl) solution, diazepam, or flumazenil. After 30 minutes, MAC was determined again. Fentanyl significantly decreased isoflurane MAC (corrected to a barometric pressure of 760 mm Hg) from 1.80+/-0.21 to 0.85+/-0.14%, a reduction of 53%. Isoflurane-fentanyl-diazepam MAC (0.48+/-0.29%) was significantly less than isoflurane-fentanyl-saline MAC (0.79+/-0.21%). Percentage reduction in isoflurane MAC was significantly greater for fentanyl-diazepam (74%), compared with fentanyl-saline (54%) ...Continue Reading

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Citations

Jul 21, 2005·New Zealand Veterinary Journal·C J Broome, V P Walsh
Dec 7, 2007·American Journal of Veterinary Research·Tokiko KushiroWilliam W Muir
Dec 13, 2007·American Journal of Veterinary Research·Daniela CampagnolEduardo R Monteiro
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Oct 18, 2006·Journal of the American Veterinary Medical Association·Kristen G Hunyady, Rebecca A Johnson
Feb 19, 2008·Journal of the American Veterinary Medical Association·Ann E Wagner, Yukari Miyake
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May 7, 2015·Veterinary Anaesthesia and Analgesia·Stephanie KeatingAndrea Edginton
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Oct 13, 2011·Veterinary Anaesthesia and Analgesia·Elise H BleijenbergLudo J Hellebrekers

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