PMID: 2494906Apr 1, 1989Paper

Effects of diazepam and flumazenil on sedation and hypoxic ventilatory response

Anesthesia and Analgesia
C T MoraP F White

Abstract

We evaluated the effects of a benzodiazepine antagonist, flumazenil (Ro 15-1788), 1 mg intravenous, on the hypoxic ventilatory response in 10 healthy patients who had received diazepam 0.97 +/- 0.34 mg/minute (mean +/- SD) for sedation during minor operative procedures. When assessed using a sedation analog scale, flumazenil significantly decreased diazepam-induced sedation. In only two of the five patients with evidence of diazepam-induced depression of the ventilatory response to hypoxia was there significant reversal of this depression after flumazenil administration. Finally, patients in whom the duration of sedation with diazepam was shorter (78 +/- 14 minutes) had a significantly greater decrease in the slope of their hypoxic ventilatory response curve (1.3 +/- 0.8 L.min-1.%sat-1 [-43% from baseline]) than did patients with longer sedation times (145 +/- 37 minutes duration; 2.0 +/- 0.8 L.min-1.%sat-1 [-5% from baseline]). These data suggest that flumazenil, 1 mg intravenous, is only partially effective in reversing diazepam-induced depression of hypoxic ventilatory drive and that tolerance may develop to the respiratory depressant effects of diazepam.

Citations

Aug 1, 1995·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·C T MoraP F White
May 1, 1996·The Journal of Emergency Medicine·C O Davis, P M Wax
Mar 25, 1998·Pharmacology, Biochemistry, and Behavior·C VerborghT F Meert
May 1, 1997·The Journal of Emergency Medicine·S P Nordt, R F Clark
Jan 1, 1990·Acta Anaesthesiologica Scandinavica. Supplementum·J G Whitwam
Oct 1, 1991·Acta Anaesthesiologica Scandinavica·J HöjerL L Gustafsson
Aug 1, 1995·Acta Anaesthesiologica Scandinavica·A MasudaY Ito
Jan 1, 1995·Acta Anaesthesiologica Scandinavica. Supplementum·J G Whitwam, R Amrein
Jan 1, 1995·Acta Anaesthesiologica Scandinavica. Supplementum·G R ParkP Ferenci
Jan 1, 1995·Acta Anaesthesiologica Scandinavica. Supplementum·R F McCloy
Sep 30, 1989·BMJ : British Medical Journal·A G Lim
Feb 17, 1990·BMJ : British Medical Journal·B R Birch, R A Miller
Jul 7, 1999·Journal of Basic and Clinical Physiology and Pharmacology·R Arieli, I Kwetny
Jan 1, 1990·Scandinavian Journal of Gastroenterology. Supplement·P M Lauven
Jul 10, 1998·Journal of Toxicology. Clinical Toxicology·C C Wiley, J F Wiley
Jan 1, 1993·Journal of Clinical Anesthesia·Y SaitoY Kosaka
Sep 1, 1992·Journal of Clinical Anesthesia·R J Fragen
Nov 14, 1997·Anesthesia and Analgesia·M M Sá RêgoP F White

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