Effects of diazepam and zolpidem on EEG beta frequencies are behavior-specific in rats

Neuropharmacology
Hester van LierA M Coenen

Abstract

A pharmacological dissociation of the relation between electroencephalographic (EEG) activity and behavior has been described for the benzodiazepines. While a decrease in high frequency EEG activity is associated with a decrease in arousal in drug-free conditions, sedative benzodiazepines increase beta activity. Non-benzodiazepine GABA(A) receptor modulators can increase beta activity as well. To further study the relationship between rat behavior and EEG under GABA(A) receptor modulation, EEG effects of diazepam (2.5 mg/kg) and zolpidem (2.5 mg/kg) were studied during different behaviors. Both drugs modulate the GABA(A) receptor, albeit that zolpidem shows alpha(1) subunit selectivity while diazepam is non-selective. A detailed analysis of rat open field behavior was made with a distinction of 25 behavioral elements. The EEG was segmented according to each behavioral element and a corresponding power spectrum calculated. Both diazepam and zolpidem increased EEG beta frequencies, characteristic for the benzodiazepines. However, the beta and gamma increase was specific for active behavior and not for inactivity. Interestingly, diazepam and zolpidem seemed to amplify, rather than dissociate, the relation between behavior and the ...Continue Reading

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Citations

Feb 29, 2008·Journal of Cognitive Neuroscience·Thomas FischerBurkhard Brocke
Oct 16, 2012·Neuropharmacology·Claudia ScheffzükJurij Brankačk
Apr 22, 2015·Seizure : the Journal of the British Epilepsy Association·Marco CambiaghiMarco Cursi
Jul 13, 2016·Behavioural Brain Research·Irene Joy I Dela PeñaJae Hoon Cheong
Apr 12, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Laura RombolàLuigi Antonio Morrone
Apr 18, 2018·Human Brain Mapping·Rachael L SumnerSuresh D Muthukumaraswamy
Nov 18, 2017·Scientific Reports·JeYoung JungMatthew A Lambon Ralph
Feb 15, 2019·The European Journal of Neuroscience·Ingeborg H HansenKjartan F Herrik
Apr 9, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dario A DornbiererHans-Peter Landolt
Jul 31, 2019·Human Brain Mapping·Jeroen Van SchependomGuy Nagels
Aug 17, 2019·Frontiers in Neuroscience·Yujiao ZhangChengbiao Lu
May 27, 2020·Scientific Reports·Daniel Simplicio TorresCarlos Eduardo Brandão-Mello

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