Effects of diazoxide on maternal and fetal circulations in normotensive and hypertensive pregnant sheep

Journal of Perinatal Medicine
H C Wallenburg, J P Kuijken

Abstract

Diazoxide is a potent antihypertensive agent due to its peripheral vasodilator action. For this reason it is used in the management of hypertensive crises in pregnancy. To assess the effects of an intravenous bolus injection of diazoxide on maternal and fetal hemodynamics an experimental study was performed in 11 chronically instrumented pregnant sheep. In six ewes hypertension was induced by surgical removal of one kidney and reduction of arterial blood flow to the remaining kidney (one-kidney renovascular hypertension). The other five ewes remained normotensive. In a second operation, one week after the first one, the animals were equipped with electromagnetic flow transducers and catheters for monitoring of blood flow in a renal, a uterine, and an umbilical artery and for measurement of maternal and fetal arterial blood pressures, and blood sampling. Maternal heart rate was derived from the arterial pressure curve, fetal heart rate from a fetal ECG. Experiments were begun on the third day after the second operation. In each experiment a bolus of 300 mg of diazoxide was administered intravenously, with or without rapid simultaneous infusion of 500 ml of a plasma expander. A total of 17 experiments were performed in the one-ki...Continue Reading

References

Jul 1, 2016·Electromagnetic Biology and Medicine·Parul ChauhanKavindra Kumar Kesari

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Related Concepts

Arterial Pulse Pressure
Fetal Structures
Collection of Blood Specimen for Laboratory Procedure
Hypertension, Renovascular
Vascular Resistance
Uterus
Blood Vessel
Intravenous Bolus
Dall Sheep
Kidney

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