PMID: 2019314Jan 1, 1991

Effects of diazoxide on the cardiovascular response to tracheal intubation

The Journal of International Medical Research
K MikawaM Kusunoki


The efficacy of 2 or 3 mg/kg diazoxide given 2.5 min before laryngoscopy in attenuating the cardiovascular responses to laryngoscopy and intubation was studied in 30 patients undergoing elective surgery. Data were compared with those from 10 control patients receiving saline. Anaesthesia was induced using 5 mg/kg thiopentone given intravenously and tracheal intubation was facilitated with 0.2 mg/kg vecuronium bromide. Patients receiving saline showed a significant increase in mean arterial pressure and rate-pressure product associated with tracheal intubation. The increases following tracheal intubation were significantly reduced (P less than 0.05) in diazoxide-treated patients compared with those in the control group, but there were no significant differences in heart rate following tracheal intubation among the three groups. Data suggest that diazoxide can be used as a supplement during induction of anaesthesia to attenuate the hypertensive response associated with laryngoscopy and tracheal intubation.


Apr 1, 1992·The Journal of International Medical Research·K MikawaH Obara


May 1, 1978·British Heart Journal·S W WangE G Wade
Feb 1, 1990·British Journal of Anaesthesia·K MikawaM Kusunoki
Jul 1, 1970·British Journal of Anaesthesia·A M Forbes, F G Dally
Jan 1, 1983·European Journal of Clinical Pharmacology·G KeuschU Binswanger

Related Concepts

Arterial Pulse Pressure
Tidal Volume
Intravenous Injections
Diastolic Blood Pressure
Tracheal Diseases
Vecuronium Bromide
Intubation, Intratracheal
Absence of Sensation

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