PMID: 8604657Jan 1, 1996Paper

Effects of diet composition and ketosis on glycemia during very-low-energy-diet therapy in obese patients with non-insulin-dependent diabetes mellitus

The American Journal of Clinical Nutrition
B GumbinerM P McDermott

Abstract

To determine whether high-ketogenic very-low-energy diets (VLEDs) can reduce hepatic glucose output (HGO) and hyperglycemia more effectively than can low-ketogenic VLEDs in obese patients with non-insulin-dependent diabetes mellitus (NIDDM), seven patients were treated with a high-ketogenic VLED for 3 wk and were compared with six patients treated with a low-ketogenic VLED. All patients were then crossed over and treated with the alternate diet for another 3 wk. Basal HGO, fasting ketone bodies, and glycemia, insulin, and C-peptide after fasting and an oral-glucose-tolerance test (OGTT) were measured. Before treatment, prediet weight and fasting, OGTT, and HGO measurements were not different between groups. After dieting, weight loss was not different between the groups. However, fasting and OGTT glycemia were lower during treatment with the high-ketogenic VLED than with the low-ketogenic VLED (treatment effect: P < 0.05, by analysis of variance). Moreover, there was a strong correlation between basal HGO and fasting plasma ketone bodies (r = -0.71 at 3 wk, r = -0.67 at 6 wk; both P < 0.05). In contrast, fasting and OGTT plasma insulin and C-peptide concentrations were not different between treatment groups. These data indicate...Continue Reading

Associated Clinical Trials

Citations

May 15, 2013·Journal of Child Neurology·Mackenzie C CervenkaJeff S Volek
Jun 27, 2013·European Journal of Clinical Nutrition·A PaoliK A Grimaldi
May 17, 2018·Physiological Reviews·Sofiya GanchevaMichael Roden
Oct 2, 2009·Current Diabetes Reports·Judith Wylie-Rosett, Nichola J Davis
Aug 10, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Allon N FriedmanJoan Temmerman
Oct 16, 2003·Journal of the American College of Nutrition·James W AndersonDavid J A Jenkins
May 18, 2013·Journal of Child Neurology·Charles V MobbsMichal Poplawski
Sep 2, 2008·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·P A Dyson
Nov 15, 2006·The Diabetes Educator·Catherine Carver
Aug 2, 2019·Cell Cycle·Mikhail V Blagosklonny
Aug 9, 2007·The American Journal of Clinical Nutrition·Eric C WestmanStephen D Phinney
May 24, 2017·Nutrients·Christophe Kosinski, François R Jornayvaz
Jun 3, 2021·International Journal of Molecular Sciences·Michael Scott Williams, Edward Turos
Aug 3, 2021·The Journal of Clinical Investigation·Dongyin Guan, Mitchell A Lazar
Mar 1, 2008·Obesity Research & Clinical Practice·Priya Sumithran, Joseph Proietto
Jun 30, 2009·Diabetes Research and Clinical Practice·Scott BakerJoseph Proietto

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.