PMID: 6990366Apr 1, 1980Paper

Effects of diet on insulin and gastric inhibitory polypeptide levels in obese children

Pediatric Research
I DeschampsH Lestradet

Abstract

To improve understanding of the relationships between gastric inhibitory polypeptide (GIP) and insulin secretion and food intake in obesity, immunoreactive insulin and immunoreactive GIP were measured in 5 obese children during PO glucose tolerance test carried out before and after diet. Before diet, mean insulin levels were normal at fasting and rose after glucose ingestion. The mean fasting immunoreactive GIP level was very high (1235 +- 209 pg/ml) compared to that of 8 healthy adult controls (411 +/- 44 pg/ml) and remained at this level throughout the test. There was only a short postabsorptive rise to 1515 +/- 158 pg/ml at 30 min, which was not significantly different either from the patients' basal values or from the 30-min control values (1356 +/- 67 pg/ml). After dieting for 3 to 7 months, immunoreactive insulin responses returned to normal ranges. Concomitantly, both basal and total GIP release diminished significantly (basal GIP, 343 +/- 92 pg/ml; area under the GIP curve, 3820 and 1694 pg/ml/hr before and after diet, respectively). The postabsorptive GIP increment, however, rose significantly from 180 pg/ml/hr, before diet, to 665 pg/ml/hr afterwards. These results might be compatible with the hypothesis that in obesi...Continue Reading

Citations

Jan 1, 1982·Acta diabetologica latina·B BeckG Debry
Jan 1, 1988·Nutrition Research Reviews·L M MorganV Marks
Jan 1, 1987·Diabetes/metabolism Reviews·R Ebert, W Creutzfeldt
Aug 1, 1985·Diabetologia·W Creutzfeldt, R Ebert
Mar 22, 2014·Annals of Surgery·Sergio Santoro
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity·Diane H Song, M Michael Wolfe
Nov 3, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity·Meena Asmar, Jens J Holst
Jun 11, 2020·The Proceedings of the Nutrition Society·Helen TrubyCatia Martins

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