PMID: 490212Oct 1, 1979Paper

Effects of dietary 3-methylthiopropionate on metabolism, growth and hematopoiesis in the rat

The Journal of Nutrition
R D SteeleN J Benevenga

Abstract

Rats were fed a basal diet supplemented with (2.57%) 3-methylthiopropionate (MTP) for 2 weeks. A marked depression in growth and food intake similar to that found in rats fed an equimolar level of methionine was observed. While supplemental glycine or serine alleviated the toxicity due to dietary methionine, similar levels added to the diets of rats fed MTP were without effect. The spleens of rats fed diets containing 2.57% MTP were grossly enlarged and darkened in comparison to spleens from control rats and histological examination of these spleens by light and transmission electron microscopy (TEM) revealed sequestration of large numbers of erythrocytes in the splenic sinusoids and red pulp similar to that seen in rats fed high levels of methionine. Marrow changes included increased numbers of erythroblastic islets and subtantial electron dense hemosiderin deposits in islet reticulum cells. Examination of peripheral blood erythrocytes by scanning electron microscopy revealed extensive variation in the size of the erythrocytes and the presence of large numbers of misshapen red cells in rats fed the diets containing MT. When viewed by TEM many erythrocytes had obvious membrane defects and remnants of cytoplasmic organellae. Man...Continue Reading

Citations

May 1, 1992·Scandinavian Journal of Gastroenterology·J MårtenssonO Weiland
Jun 17, 2008·The Journal of Pharmacology and Experimental Therapeutics·Joseph T Dever, Adnan A Elfarra
May 17, 2006·The Journal of Nutrition·Sakino ToueRyosei Sakai
Aug 9, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Joseph T Dever, Adnan A Elfarra
Nov 29, 2014·Critical Reviews in Microbiology·Emiliano Salvucci
Sep 30, 2010·Expert Opinion on Drug Metabolism & Toxicology·Joseph T Dever, Adnan A Elfarra
Jan 25, 2018·Annals of the New York Academy of Sciences·Anna K ShovellerJohn P Cant
Jun 3, 2004·The Journal of Nutrition·Peter J Garlick
Apr 1, 1986·Analytical Biochemistry·J Mårtensson
Sep 16, 1982·Biochemical and Biophysical Research Communications·H Ogawa, M Fujioka

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