PMID: 6161235Nov 1, 1980Paper

Effects of dietary amino acids on brain amino acids and transmitter amines in rats with a portacaval shunt

Journal of Neurochemistry
S KamataH Wada

Abstract

The etiologic relationship between disturbances in metabolism of amino acids and amines and hepatic coma was investigated by examining the effects of diets containing various mixtures of amino acids on brain amine metabolism in rats with a portacaval shunt, using a method for simultaneous analysis of amino acids and amines. Rats with a portacaval shunt were fed on four different amino acid compositions with increased amounts of various amino acids suspected to be etiologically related to hepatic coma, such as methionine, phenylalanine, tyrosine, and tryptophan. The animals were killed 4 weeks after operation. During the experimental period, these animals did not become comatose, but exhibited various behavioral abnormalities. Marked increase in the plasma and brain levels of the augmented amino acids, especially methionine and tyrosine, were observed in rats with a portacaval shunt. Brain noradrenaline, dopamine, and serotonin levels were significantly decreased when the brain tyrosine level was increased. These results indicate that in rats with a portacaval shunt the dietary levels of amino acids greatly influence the brain levels of both amino acids and transmitter amines.

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Citations

Jun 1, 1993·Amino Acids·D R DeshmukhM Portoles
Mar 1, 1986·Metabolic Brain Disease·A M Mans, R A Hawkins
Feb 1, 1987·Neurochemical Pathology·R A HawkinsJ F Biebuyck
May 31, 1991·Clinica Chimica Acta; International Journal of Clinical Chemistry·T YonekuraS Tarui
May 1, 1986·Pharmacology, Biochemistry, and Behavior·K ImuraH Wada
Oct 3, 1985·The New England Journal of Medicine·C L Fraser, A I Arieff
Jan 1, 1992·Drug and Alcohol Review·J E Maddison
Nov 1, 1992·Journal of Veterinary Internal Medicine·J E Maddison

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