Effects of dietary carbohydrate and myo-inositol on metabolic changes in rats fed 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane (DDT)

The Journal of Nutritional Biochemistry
Yukako Okazaki, Tetsuyuki Katayama


This study was conducted to examine the effects of dietary carbohydrate [starch or sucrose (500 g/kg diet)] and myo-inositol (2 g/kg diet) on metabolic changes in rats fed 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane (DDT) (0.7 g/kg diet). Dietary DDT enhanced serum and hepatic lipids and hepatic thiobarbituric acid reactive substances (TBA-RS), elevated hepatic activities of lipogenic enzymes such as malic enzyme (ME), glucose-6-phosphate dehydrogenase (G6PD) and fatty acid synthetase (FAS), increased hepatic cytochrome P-450 content and the activities of drug-metabolizing enzymes such as aminopyrine N-demethylase, glutathione S-transferase and 4-nitrophenol-UDP glucuronosyltransferase (4NP-UDPGT) and raised hepatic ascorbic acid and serum copper. Dietary sucrose promoted the increases in hepatic concentrations of total lipids, triglyceride and cholesterol, hepatic activity of ME, hepatic TBA-RS, cytochrome P-450 content and serum copper due to DDT feeding when compared to DDT administered in a starch based diet. Dietary myo-inositol significantly depressed the rises in hepatic concentrations of total lipids, triglyceride and cholesterol and the activities of ME and G6PD due to DDT feeding regardless of dietary carbohydrate...Continue Reading


Jan 1, 1978·Methods in Enzymology·J B Schenkman, D L Cinti
Jul 1, 1975·The Journal of Nutrition·S ReiserJ Hallfrisch
Oct 1, 1992·Journal of Nutritional Science and Vitaminology·H DannoS Kimura
Feb 1, 1991·European Journal of Clinical Investigation·P A Cerutti
Jul 1, 1991·Chemical Research in Toxicology·F P Guengerich, T Shimada
Jan 1, 1986·Annual Review of Nutrition·B J Holub
Aug 1, 1987·Journal of Nutritional Science and Vitaminology·H OhchiN Kato
Apr 1, 1967·The Journal of Nutrition·R A Freedland
Jul 15, 1981·The Biochemical Journal·P Martyn, I A Hansen
Feb 1, 1984·The American Journal of Clinical Nutrition·M FieldsS Reiser
Mar 1, 1982·The Journal of Nutrition·F Horio, A Yoshida
Jan 1, 1993·Bioscience, Biotechnology, and Biochemistry·Y HitomiA Yoshida

❮ Previous
Next ❯


Mar 3, 2007·Journal of Nutritional Science and Vitaminology·Naoto HashimotoMichihiro Fukushima
May 1, 2004·Proceedings of the National Academy of Sciences of the United States of America·J H F PedraBarry R Pittendrigh
Jun 25, 2004·Bioscience, Biotechnology, and Biochemistry·Shoko OnomiTetsuyuki Katayama
Sep 18, 2015·Molecular Genetics and Genomics : MGG·Yuan LvChangliang Zhu
Aug 3, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J JanosekI Holoubek
Dec 21, 2019·Archives of Insect Biochemistry and Physiology·Min LiaoHaiqun Cao

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.