Effects of dietary carbohydrate and myo-inositol on metabolic changes in rats fed 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane (DDT)

The Journal of Nutritional Biochemistry
Yukako Okazaki, Tetsuyuki Katayama

Abstract

This study was conducted to examine the effects of dietary carbohydrate [starch or sucrose (500 g/kg diet)] and myo-inositol (2 g/kg diet) on metabolic changes in rats fed 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane (DDT) (0.7 g/kg diet). Dietary DDT enhanced serum and hepatic lipids and hepatic thiobarbituric acid reactive substances (TBA-RS), elevated hepatic activities of lipogenic enzymes such as malic enzyme (ME), glucose-6-phosphate dehydrogenase (G6PD) and fatty acid synthetase (FAS), increased hepatic cytochrome P-450 content and the activities of drug-metabolizing enzymes such as aminopyrine N-demethylase, glutathione S-transferase and 4-nitrophenol-UDP glucuronosyltransferase (4NP-UDPGT) and raised hepatic ascorbic acid and serum copper. Dietary sucrose promoted the increases in hepatic concentrations of total lipids, triglyceride and cholesterol, hepatic activity of ME, hepatic TBA-RS, cytochrome P-450 content and serum copper due to DDT feeding when compared to DDT administered in a starch based diet. Dietary myo-inositol significantly depressed the rises in hepatic concentrations of total lipids, triglyceride and cholesterol and the activities of ME and G6PD due to DDT feeding regardless of dietary carbohydrate...Continue Reading

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Citations

Mar 3, 2007·Journal of Nutritional Science and Vitaminology·Naoto HashimotoMichihiro Fukushima
May 1, 2004·Proceedings of the National Academy of Sciences of the United States of America·J H F PedraBarry R Pittendrigh
Jun 25, 2004·Bioscience, Biotechnology, and Biochemistry·Shoko OnomiTetsuyuki Katayama
Sep 18, 2015·Molecular Genetics and Genomics : MGG·Yuan LvChangliang Zhu
Aug 3, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J JanosekI Holoubek
Dec 21, 2019·Archives of Insect Biochemistry and Physiology·Min LiaoHaiqun Cao

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