PMID: 3746458Jul 1, 1986Paper

Effects of dietary carbohydrate on hepatic gluconeogenesis in BHE rats

The Journal of Nutrition
J H ParkB Szepesi

Abstract

The effects of feeding different carbohydrates on hepatic gluconeogenesis in BHE rats was studied. Three experiments were conducted that differed only in the aspects of gluconeogenesis examined. In experiment 1, gluconeogenesis and ketogenesis by hepatocytes isolated from 48-h starved rats were determined. In experiment 2, the activities of selected gluconeogenic enzymes were determined in starved and nonstarved rats. In experiment 3, the levels of the various metabolites of glycolysis and the citric acid cycle were determined in nonstarved rats. Rats were fed diets containing starch, maltose, glucose, sucrose or an equimolar mixture of glucose and fructose. In starved rats, gluconeogenesis was less in starch-fed rats than in rats fed any of the sugar diets. These same diet differences, with few exceptions, were also observed in ketogenesis. Glucose 6-phosphatase activity was lower in nonstarved rats fed starch and maltose than in rats fed glucose, sucrose, or glucose and fructose. These same nonstarved rats also had lower phosphoenolpyruvate carboxykinase and higher glutamate pyruvate transaminase activities than rats fed the other diets. In the starved rats, the diet differences were erased. Starved rats had lower activities ...Continue Reading

Citations

Jul 13, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M E BizeauM J Pagliassotti
Apr 5, 2001·American Journal of Physiology. Endocrinology and Metabolism·M E BizeauM J Pagliassotti
Oct 20, 2001·Journal of Applied Physiology·M E BizeauM J Pagliassotti
Jun 15, 2007·American Journal of Physiology. Cell Physiology·Carolyn D Berdanier
Jun 1, 1988·Biochemical Pharmacology·O A Forsander, A R Pösö
May 1, 1990·The Journal of Nutritional Biochemistry·J S Pan, C D Berdanier

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