Effects of dietary Clostridium butyricum supplementation on growth performance, intestinal development, and immune response of weaned piglets challenged with lipopolysaccharide

Journal of Animal Science and Biotechnology
Ling Chen De Wu

Abstract

Weanling pigs, with immature immune system and physiological function, usually experience post-weaning diarrhea. This study determined the effects of dietary Clostridium butyricum supplementation on growth performance, diarrhea, and immunity of weaned pigs challenged with lipopolysaccharide (LPS). In Experiment (Exp.) 1, 144 weaned piglets were weaned at 21 d and randomly assigned to six groups, with six replicates per group and four pigs per replicate, receiving a control diet (CON) or diet supplemented with antibiotics (AB) or C. butyricum (CB) (0.1%, 0.2%, 0.4%, or 0.8%), respectively. All diets in Exp. 1 were a highly digestible basal diet, with 3,000 mg/kg zinc oxide supplied in the first 2 wk only. In Exp. 2, 180 piglets were weaned at 21 d and randomly assigned to five groups, with six replicates per group and six pigs per replicate, receiving CON, AB, or CB (0.2%, 0.4%, or 0.6%) diets. The digestibility of diets was lower than those in Exp. 1, and did not include zinc oxide. At 36 d of Exp. 2, 12 piglets were selected from each of the CON and 0.4% CB groups, six piglets were intraperitoneally injected with LPS (50 μg/kg body weight) and the other six piglets with normal saline; animals were killed at 4 h after injection...Continue Reading

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Citations

Apr 23, 2019·Journal of Animal Physiology and Animal Nutrition·Ji Fa ChenSongchang Guo
Mar 25, 2020·Journal of Animal Physiology and Animal Nutrition·Jiayun QiaoYupeng Li
Nov 4, 2020·Journal of the Science of Food and Agriculture·Dingfa WangGuanyu Hou
Aug 8, 2021·Animals : an Open Access Journal From MDPI·María Bernad-RocheRaúl Carlos Mainar-Jaime

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Methods Mentioned

BETA
scraping
PCR
electrophoresis

Software Mentioned

Uparse

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