Effects of Dietary Exposure to Zearalenone (ZEN) on Carp (Cyprinus carpio L.)

Toxins
Constanze PietschRanka Junge

Abstract

The mycotoxin zearalenone (ZEN) is frequently contaminating animal feeds including feed used in aquaculture. In the present study, the effects of dietary exposure to ZEN on carp (Cyprinus carpio L.) were investigated. ZEN at three different concentrations (low dose: 332 µg kg(-1), medium dose: 621 µg kg(-1) and high dose: 797 µg kg(-1) final feed, respectively) was administered to juvenile carp for four weeks. Additional groups received the mycotoxin for the same time period but were fed with the uncontaminated diet for two more weeks to examine the reversibility of the ZEN effects. No effects on growth were observed during the feeding trial, but effects on haematological parameters occurred. In addition, an influence on white blood cell counts was noted whereby granulocytes and monocytes were affected in fish treated with the medium and high dose ZEN diet. In muscle samples, marginal ZEN and α-zearalenol (α-ZEL) concentrations were detected. Furthermore, the genotoxic potential of ZEN was confirmed by analysing formation of micronuclei in erythrocytes. In contrast to previous reports on other fish species, estrogenic effects measured as vitellogenin concentrations in serum samples were not increased by dietary exposure to ZEN....Continue Reading

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Citations

Oct 23, 2015·BioMed Research International·Constanze PietschPatricia Burkhardt-Holm
Dec 13, 2019·International Journal of Microbiology·Esther MarijaniSheila Okoth
Jul 31, 2017·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Isabelle P Oswald
Jul 28, 2019·Mycotoxin Research·Constanze Pietsch
Jan 10, 2021·Toxins·Karolina Ropejko, Magdalena Twarużek
Mar 14, 2021·Food Chemistry·Esther De RyckeNatalia Beloglazova

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