Effects of dietary fat modification on fibrinogen, factor VII, and plasminogen activator inhibitor-1 activity in subjects with impaired glucose tolerance

Metabolism: Clinical and Experimental
L NiskanenM I Uusitupa

Abstract

Our aim was to assess the impact of a monounsaturated fat-enriched (Mono) diet and a diet recommended by the National Cholesterol Education Program (NCEP) on plasma levels of fibrinogen and activities of factor VII (FVII:C) and plasminogen activator inhibitor-1 (PAI-1) and the impact of genetic polymorphisms of these variables (HaeIII, MspI, and 4G/5G polymorphisms, respectively) in 28 subjects with impaired glucose tolerance ([IGT] 17 men and 11 women; mean age, 55.6 +/- 5.5 years). A diet rich in fat and saturated fatty acids served as a baseline diet for 3 weeks. Thereafter, subjects were randomized for the next 8 weeks to either the Mono diet (n = 12) or NCEP diet (n = 18). Fibrinogen levels or PAI-1 activities did not change with either of the diets, but fibrinogen levels were higher (3.4 +/- 0.5 v 4.0 +/- 0.6 g/L, P = .007 at baseline) throughout the study in heterozygous subjects with respect to HaeIII polymorphism. This polymorphism and age accounted for 38% of the variation of fibrinogen levels. MspI polymorphism together with body mass index explained 51% of the variation of FVII:C, which was higher in subjects with the M1M1 genotype compared with M1M2/M2M2 genotypes (127% +/- 21% v 90% +/- 12%, P < .001). FVII:C show...Continue Reading

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Citations

Dec 28, 1999·Public Health Nutrition·R Rauramaa, S B Väisänen
Apr 19, 2007·Molecular Nutrition & Food Research·Rafael Angel Fernández de la PueblaFrancisco Pérez-Jiménez
Oct 16, 2004·Current Atherosclerosis Reports·Brent D Flickinger, Peter J Huth
Jul 20, 2001·Annals of the New York Academy of Sciences·M P de Maat
Sep 21, 2007·Molecular Nutrition & Food Research·Jose Lopez-MirandaCarmen Marin
Jun 29, 2005·Journal of the American Dietetic Association·Margaret A Allman-FarinelliPeter Petocz
May 28, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Asim K Duttaroy

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