PMID: 6975360Nov 1, 1981Paper

Effects of dietary fatty acids on delayed-type hypersensitivity in mice

The Journal of Nutrition
J W DeWilleD R Romsos

Abstract

Effects of an essential fatty acid deficient (EFAD) [0% corn oil (CO)] diet and a diet high in polyunsaturated fatty acids [PUFA (50% CO)] on one aspect of in vivo T cell function [delayed-type hypersensitivity (DTH)] were assessed. After a 70-day feeding trial, DTH was reduced by 30% in mice fed the EFAD diet, but the response of mice fed the high PUFA diet equaled that of control mice fed a diet containing 13% CO. The time required for the EFAD diet to reduce DTH was 42 days. Although consumption of the EFAD diet reduced DTH, this reduction was rapidly reversed, within 7 days, by switching the EFAD mice to the control diet. These results indicate that :1) consumption of the EFAD diet reduces one aspect of in vivo T cell function (DTH), but the effect can be reversed by refeeding the control diet; and 2) a high PUFA diet does not adversely affect DTH.

Citations

Jan 1, 1992·The British Journal of Nutrition·R W CrevelW E Parish
Mar 3, 1998·Nutrition Reviews·P C Calder
Sep 5, 2002·The British Journal of Nutrition·Ruud AlbersRaymond Pieters
Jul 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·J Palmblad, H Gyllenhammar
Jul 1, 1992·JPEN. Journal of Parenteral and Enteral Nutrition·P Clouva-MolyvdasJ W Alexander
Jun 1, 1992·Italian Journal of Neurological Sciences·V GallaiD Murasecco
Jul 1, 1985·The Proceedings of the Nutrition Society·A D SmithJ Belin
Nov 1, 1988·Photochemistry and Photobiology·V E ReeveC H Gallagher
May 26, 1999·FEMS Immunology and Medical Microbiology·C Romano CarratelliF Galdiero
Jan 1, 1986·International Journal of Immunopharmacology·K L Erickson
Jan 1, 1983·Progress in Lipid Research·M I Gurr

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