Effects of dietary fish oil on renal growth and function in uninephrectomized rats

Kidney International
J L LoganB Benson

Abstract

The basic mechanisms of renal growth remain poorly understood. The work hypertrophy theory holds that after an acute reduction in renal mass, the growth of the kidney occurs as a consequence of increased renal function. Pharmacological inhibition of renal prostaglandin synthesis impairs the acute adaptive increases in both renal function and mass following partial nephrectomy. The present study examines the effects of four weeks of dietary fish oil on renal growth, function and arachidonic acid metabolites in intact and uninephrectomized male Sprague-Dawley rats. Dietary fish oil interferes with dienoic prostaglandin and thromboxane production in favor of synthesis of trienoic analogues. Control animals were pair-fed an identical diet with the exception that the fat was replaced by beef tallow. Renal cortical concentrations of arachidonic acid metabolites were reduced in animals fed fish oil, and urinary excretion of prostaglandin E2 was impaired. Fish oil feeding resulted in increased kidney weight without concomitant increases in renal function in intact animals. Glomerular filtration rate and renal plasma flow were greater in uninephrectomized rats fed fish oil compared to uninephrectomized controls pair-fed beef tallow. Aug...Continue Reading

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Citations

Jun 1, 1996·Diabetes Research and Clinical Practice·J L Logan
Dec 1, 1990·Baillière's Clinical Endocrinology and Metabolism·C D Short, P N Durrington
Oct 1, 1994·Australian Veterinary Journal·J E Bauer
Sep 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R De CaterinaE B Schmidt
Oct 1, 1993·Kidney International·R De CaterinaP Rindi
Jun 1, 1991·Kidney International·B L KasiskeW F Keane
Nov 1, 1990·Prostaglandins, Leukotrienes, and Essential Fatty Acids·J L Logan, B Benson
Dec 21, 2002·The British Journal of Nutrition·Irene L BlackMichael J Gibney

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