Effects of Dietary Intake of Japanese Mushrooms on Visceral Fat Accumulation and Gut Microbiota in Mice

Nutrients
Takamitsu ShimizuTsuyoshi Tsuduki

Abstract

A lot of Japanese people are generally known for having a healthy diet, and consume a variety of mushrooms daily. Many studies have reported anti-obesity effects of mushrooms, but few have investigated the effects of consuming a variety of edible mushroom types together in realistic quantities. In this study, we investigated whether supplementation with a variety of mushroom types affects visceral fat accumulation and gut microbiota in mice. The most popular mushroom varieties in Japan were lyophilized and mixed according to their local production ratios. C57BL/6J mice were fed a normal diet, high-fat (HF) diet, HF with 0.5% mushroom mixture (equivalent to 100 g mushrooms/day in humans) or HF with 3% mushroom mixture (equivalent to 600 g mushrooms/day in humans) for 4 weeks. The mice were then sacrificed, and blood samples, tissue samples and feces were collected. Our results show that mushroom intake suppressed visceral fat accumulation and increased the relative abundance of some short chain fatty acid- and lactic acid-producing gut bacteria. These findings suggest that mushroom intake is an effective strategy for obesity prevention.

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Citations

Jan 18, 2020·Annual Review of Food Science and Technology·Yanhui Han, Hang Xiao
Apr 8, 2020·Bioscience, Biotechnology, and Biochemistry·Masaki AsanoTsuyoshi Tsuduki
Aug 26, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Emanuel VamanuIonela Sârbu
Oct 18, 2019·Journal of Nutritional Science and Vitaminology·Ran OkouchiTsuyoshi Tsuduki
Jan 11, 2020·Food & Nutrition Research·Fenfen WeiBo Zhang
Nov 3, 2020·Frontiers in Nutrition·Hongzhen SangJunpeng Wang
Jul 3, 2021·Microorganisms·Emanuel VamanuFlorentina Gatea
Dec 27, 2021·FEBS Letters·Robert B BeelmanMichael D Kalaras

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Methods Mentioned

BETA
ELISA
PCR

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