Effects of dietary paraffin, squalane and sucrose polyester on residue disposition and elimination of hexachlorobenzene in rats

Chemico-biological Interactions
E RichterS G Schäfer

Abstract

Previous studies have shown addition of light liquid paraffin to enhance the elimination of organochlorine xenobiotics. In the present study the effect of paraffin on the elimination of [14C]hexachlorobenzene (HCB) was compared with the effect of possible alternative compounds, squalane and sucrose polyester (SPE). Four groups of 7 rats were fed a diet containing 1.5 ppm [14C]HCB for 4 days followed by 10 days on HCB-free diet. Thereafter one group (control) remained on this diet whereas the other 3 groups received a diet supplemented with 8% (w/w) paraffin, squalane or SPE, respectively. Radioactivity in urine and faeces was measured daily and at the end of the experiment in samples of abdominal fat, muscle, liver, kidney and blood. Dietary treatment with either paraffin, squalane or SPE markedly enhanced faecal excretion of [14C]HCB, whereas urinary excretion was not affected. Both the time course as well as the extent of faecal [14C]HCB elimination were similar in the treated groups. After 3 weeks of treatment the amount of [14C]HCB excreted with faeces was about three times higher in treated animals than in controls. The half-life (t1/2) of [14C]HCB elimination from the body was markedly decreased in treated animals (mean 3...Continue Reading

References

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Citations

Oct 1, 1982·Bulletin of Environmental Contamination and Toxicology·S G SchäferE Richter
Jan 1, 1982·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·E Richter, S G Schäfer
Feb 9, 2002·Lipids·Ronald J Jandacek, Patrick Tso
May 1, 1983·Journal of Toxicology. Clinical Toxicology·W J Decker
Jun 1, 1983·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·E RichterB Fichtl
May 1, 1988·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·H KamimuraM Nakano
Oct 30, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ronald J JandacekPatrick Tso
Apr 11, 2019·Frontiers in Bioengineering and Biotechnology·Nisarg GohilVijai Singh

Related Concepts

Sucrose polyester
Squalane
Fat Pad
Metazoa
Chlorobenzenes
Diet
Saturated Fat
Feces
Hexachlorobenzene
Kidney

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