Effects of dietary phosphate on glucose and lipid metabolism

American Journal of Physiology. Endocrinology and Metabolism
Maerjianghan AbuduliYutaka Taketani

Abstract

Recent epidemiological and animal studies have suggested that excess intake of phosphate (Pi) is a risk factor for the progression of chronic kidney disease and its cardiovascular complications. However, little is known about the impact of dietary high Pi intake on the development of metabolic disorders such as obesity and type 2 diabetes. In this study, we investigated the effects of dietary Pi on glucose and lipid metabolism in healthy rats. Male 8-wk-old Sprague-Dawley rats were divided into three groups and given experimental diets containing varying amounts of Pi, i.e., 0.2 [low Pi(LP)], 0.6 [control Pi(CP)], and 1.2% [high Pi(HP)]. After 4 wk, the HP group showed lower visceral fat accumulation compared with other groups, accompanied by a low respiratory exchange ratio (V̇CO2/V̇O2) without alteration of locomotive activity. The HP group had lower levels of plasma insulin and nonesterified fatty acids. In addition, the HP group also showed suppressed expression of hepatic lipogenic genes, including sterol regulatory element-binding protein-1c, fatty acid synthase, and acetyl-CoA carboxylase, whereas there was no difference in hepatic fat oxidation among the groups. On the other hand, uncoupling protein (UCP) 1 and peroxiso...Continue Reading

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Citations

Feb 18, 2020·Clinical Science·Carla El-Mallah, Omar Obeid
Sep 29, 2017·Journal of Clinical Biochemistry and Nutrition·Kohei SugiharaYutaka Taketani
Nov 30, 2018·Journal of Clinical Biochemistry and Nutrition·Yukiko ImiYutaka Taketani
Oct 7, 2020·Nutrients·Maria MirabelliAntonio Brunetti
Oct 14, 2020·Genome Medicine·Dana BinyaminOmry Koren
Mar 30, 2021·Clinical Kidney Journal·Paula EsquinasIgnacio Lopez
Sep 24, 2021·Genetics, Selection, Evolution : GSE·Miguel Gozalo-MarcillaRoger Ros-Freixedes

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