Effects of dietary supplementation with arachidonic acid rich oils on nerve conduction and blood flow in streptozotocin-diabetic rats

Prostaglandins, Leukotrienes, and Essential Fatty Acids
M A Cotter, N E Cameron

Abstract

Diabetes mellitus is associated with defective essential fatty acid desaturation. In experimental models this contributes to characteristic reductions in peripheral nerve conduction velocity (NCV) and blood flow, which may be corrected by dietary supplementation with gamma-linolenic acid (GLA) rich oils to bypass the delta-6 desaturation deficit. There is debate about the mechanism of this improvement, including whether it depends on synthesis of series 1 prostanoids derived from di-homo GLA or series 2 prostanoids from arachidonic acid (ARA). The aim was to assess the efficacy of two ARA-rich (approximately 39% content) oils in correcting neurovascular dysfunction in streptozotocin-induced diabetic rats. After 6 weeks of untreated diabetes, rats were treated for a further 2 weeks with 1% dietary oil supplements before assessment of sciatic motor NCV and endoneurial blood flow. NCV was 19% reduced in diabetic rats and this was largely (approximately 86%) corrected by both oil treatments. A 48% deficit in endoneurial nutritive blood flow with diabetes was approximately 70% reversed by the two oils, vascular conductance being in the non-diabetic range. Thus, nerve conduction and perfusion deficits in diabetic rats are corrected b...Continue Reading

References

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Oct 1, 1988·The Journal of Diabetic Complications·P O Julu
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Dec 1, 1964·The Journal of Clinical Investigation·S G ELIASSON

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Citations

Nov 13, 2003·Current Diabetes Reports·Angelika BierhausPeter P Nawroth
Jan 29, 1997·European Journal of Pharmacology·N E Cameron, M A Cotter
Dec 10, 1999·Diabetes Research and Clinical Practice·N E Cameron, M A Cotter
Dec 17, 2005·Antioxidants & Redox Signaling·Aaron P Kellogg, Rodica Pop-Busui
Jul 30, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Kun-Teng WangChing-Chiung Wang
Jan 11, 2011·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Ganapathy Saravanan, Ponnusamy Ponmurugan

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