Effects of dietary treatment alone or diet with voglibose or glyburide on abdominal adipose tissue and metabolic abnormalities in patients with newly diagnosed type 2 diabetes

Diabetes Care
Kazuhisa TakamiKeigo Yasuda

Abstract

OBJECTIVE; To examine the effects of diet and diet with voglibose or glyburide on abdominal adiposity and metabolic abnormalities in patients with type 2 diabetes. A total of 36 Japanese patients with newly diagnosed type 2 diabetes (50.8 +/- 8.6 years of age, BMI 24.5 +/- 3.5 kg/m(2)) and 273 normal control subjects were studied. The patients were treated for 3 months with diet alone (30 kcal/kg per day) (n = 15), diet with voglibose (n = 12), or diet with glyburide (n = 9). They underwent 75-g oral glucose tolerance testing, assessment of insulin sensitivity (SI), and acute insulin response (AIR) with intravenous glucose tolerance testing based on the minimal model, and measurement of abdominal visceral adipose tissue area (VAT) and subcutaneous adipose tissue area (SAT) by computed tomography before and after treatment. The diabetic patients had comparable SAT but larger VAT than the control subjects. With a mean weight loss of 2-3 kg, VAT and SAT were decreased similarly in all treatment groups. The VAT-to-SAT ratio was decreased only in the voglibose group. Glycemic control and serum lipid profiles were improved in all groups. Changes in glycemic control after diet were closely correlated with changes in VAT but not with c...Continue Reading

References

Oct 1, 1991·The American Journal of Clinical Nutrition·D S GrayT Pappas
Oct 1, 1988·Diabetic Medicine : a Journal of the British Diabetic Association·H Beck-NielsenO Pedersen
Jun 1, 1986·Investigative Radiology·W P ShumanW Y Fujimoto
May 20, 1998·Diabetes·N RudermanS Schneider
Jun 24, 2000·Diabetes·C T Montague, S O'Rahilly

❮ Previous
Next ❯

Citations

Jul 23, 2011·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Tae SasakabeKenji Wakai
Dec 3, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Vishal DiwanLindsay Brown
Sep 18, 2004·Metabolism: Clinical and Experimental·Tsukasa NakamuraHikaru Koide
Apr 23, 2005·The Cochrane Database of Systematic Reviews·F A Van de LaarC Van Weel

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.

Related Papers

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Yang JihongTatsuo Umemura
© 2022 Meta ULC. All rights reserved