PMID: 2508746Oct 17, 1989Paper

Effects of dietary vitamin E on the biosynthesis of 5-lipoxygenase products by rat polymorphonuclear leukocytes (PMNL)

Biochimica Et Biophysica Acta
A C ChanW S Powell

Abstract

Activation of polymorphonuclear neutrophils (PMNL) leads to the release of arachidonate from cellular phospholipids via a phospholipase A2, and conversion of products of the 5-lipoxygenase pathway. Evidence to date indicates the dietary vitamin E ((R,R,R)-alpha-tocopherol) can influence both cyclooxygenase and phospholipase A2 activities and that the effect of this vitamin is cell/tissue specific. The present study was undertaken in order to examine the effects of varying dietary tocopherol on PMNL tocopherol content and 5-lipoxygenase product profile using the ionophore A23187 as stimulant in the presence and absence of exogenous arachidonate. Feeding semi-purified diets containing 0, 30 or 3000 ppm of (R,R,R)-alpha-tocopherol acetate to weanling rats for 17 weeks resulted in a dose-related enrichment of PMNL tocopherol. Stimulation of PMNL elicited a significant and rapid loss of tocopherol. When PMNL were stimulated with A23187 alone, the synthesis of 5-HETE, LTB4 and 19-hydroxy-LTB4 was decreased in proportion to increasing dietary tocopherol concentrations. However, when exogenous arachidonate was provided with A23187, intermediate amounts of dietary tocopherol (30 ppm) still suppressed the formation of 5-lipoxygenase prod...Continue Reading

References

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Citations

Aug 25, 2001·Journal of Physiology and Biochemistry·E Herrera, C Barbas
Jun 1, 1995·Toxicology in Vitro : an International Journal Published in Association with BIBRA·R Sujatha, L Srinivas
Mar 1, 1996·Journal of Lipid Mediators and Cell Signalling·P O Julu
Feb 3, 2000·Free Radical Biology & Medicine·W A Pryor
Jul 18, 2002·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·F A WengerJ M Müller
Feb 24, 2007·Molecular Aspects of Medicine·Elke ReiterStephan Christen
Jul 20, 1992·FEBS Letters·C T Ho, A C Chan
Apr 9, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·S Devaraj, I Jialal
Sep 1, 1993·Journal of Dairy Science·J S HoganK L Smith
Feb 17, 2001·Journal of Applied Toxicology : JAT·A M Sciuto, T S Moran
Oct 15, 1998·The Journal of Nutrition·A C Chan
Feb 13, 2001·The Journal of Nutrition·I JialalN Kaul
Dec 1, 2001·Prostaglandins, Leukotrienes, and Essential Fatty Acids·F A WengerJ M Müller
Jul 8, 1991·Biochimica Et Biophysica Acta·W SakamotoM Mino
Oct 1, 1991·Prostaglandins, Leukotrienes, and Essential Fatty Acids·W SakamotoS Murota
Mar 1, 1990·Archives of Biochemistry and Biophysics·D D Pyke, A C Chan

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