PMID: 6164771May 1, 1981Paper

Effects of dietary wheat bran on rat colonic structure and mucosal cell growth

The Journal of Nutrition
L R Jacobs, B O Schneeman

Abstract

The effects of dietary wheat bran on colonic morphology and mucosal cell growth were examined in male Wistar rats. Two groups of rats were fed defined diets for 2 weeks. The control group was fed a fiber-free diet while the experimental group received the same diet plus a 20% wheat bran supplement. Nutrient intake and body weight gain were similar in the two groups of rats. The bran-fed group developed an increase in proximal (cecum) and distal colonic weights (P less than 0.02 0.02) but mucosal weight was only increased in the distal colon when compared to the control group (P less than 0.005). Histological measurements revealed deeper colonic crypts (P less than 0.001) and mucosal cell hyperplasia in the bran-fed group in addition to an increase in muscle thickness (P less than 0.001). Mucosal cell hyperplasia, as measured by the increases in mucosal protein (P less than 0.01), DNA (P less than 0.01) and RNA (P less than 0.005) was most marked in the distal colon. Proximal colon showed no significant change in mucosal cell mass. Cell RNA content was decreased only in the proximal colonic mucosa (P less than 0.01). These results demonstrate that dietary wheat bran regulates colonic mucosal cell growth according to the anatomic...Continue Reading

Citations

Mar 1, 1989·JPEN. Journal of Parenteral and Enteral Nutrition·S A KripkeJ L Rombeau
Nov 1, 1989·The Diabetes Educator·J Tietyen
Mar 1, 1985·Digestive Diseases and Sciences·L R Jacobs
Apr 14, 2016·Molecular Nutrition & Food Research·Caroline ThumNicole C Roy
Jan 1, 2016·Journal of Food and Drug Analysis·Lokesh Kumar BooupathyBalasubramanian Maruthaiveeran Periyasamy
Feb 15, 1988·International Journal of Cancer. Journal International Du Cancer·M TatsutaH Taniguchi

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