Effects of diets enriched in n-6 or n-3 fatty acids on cholesterol metabolism in older rats chronically fed a cholesterol-enriched diet

Lipids
M FukushimaM Nakano

Abstract

Hypocholesterolemic effects in older animals after long-term feeding are unknown. Therefore, aged rats (24 wk of age) fed a conventional diet were shifted to diets containing 10% perilla oil [PEO; oleic acid + linoleic acid + alpha-linolenic acid; n-6/n-3, 0.3; polyunsaturated fatty acid/saturated fatty acid (P/S), 9.6], borage oil [oleic acid + linoleic acid + alpha-linolenic acid; n-6/n-3, 15.1; P/S, 5.3], evening primrose oil (EPO; linoleic acid + gamma-linolenic acid; P/S, 10.5), mixed oil (MIO; oleic acid + linoleic acid + gamma-linolenic acid + alpha-linolenic acid; n-6/n-3, 1.7; P/S, 6.7), or palm oil (PLO; palmitic acid + oleic acid + linoleic acid; n-6/n-3, 25.3; P/S, 0.2) with 0.5% cholesterol for 15 wk in this experiment. There were no significant differences in the food intake and body weight gain among the groups. The liver weight in the PEO (n-6/n-3, 0.3) group was significantly higher than those of other groups in aged rats. The serum total cholesterol and very low density lipoprotein (VLDL) + intermediate density lipoprotein (IDL) + low density lipoprotein (LDL)-cholesterol concentrations of the PLO (25.3) group were consistently higher than those in the other groups. The serum high density lipoprotein cholester...Continue Reading

Citations

Jun 11, 2005·The British Journal of Nutrition·Lin YangZhen-Yu Chen
Nov 21, 2009·Journal of Nutritional Science and Vitaminology·Hiroyuki TakeuchiTatsuhiro Matsuo
May 13, 2005·Mechanisms of Ageing and Development·M F MulasS Dessi
Mar 7, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Adriana R Schultz MoreiraFrancisco J Sánchez-Muniz
Sep 12, 2006·Biochemical and Biophysical Research Communications·Arunabh BhattacharyaGabriel Fernandes
Mar 24, 2006·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mounia CherkiAbdelouahed Khalil
May 31, 2017·The Journal of Pharmacy and Pharmacology·Shilpi SinghSuaib Luqman

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